1. Bottom-Up Preparation of Uniform Ultrathin Rhenium Disulfide Nanosheets for Image-Guided Photothermal Radiotherapy.
- Author
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Shen, Sida, Chao, Yu, Dong, Ziliang, Wang, Guanglin, Yi, Xuan, Song, Guosheng, Yang, Kai, Liu, Zhuang, and Cheng, Liang
- Subjects
RHENIUM compounds ,RADIOTHERAPY ,POLYETHYLENE glycol ,ACOUSTIC imaging ,SURFACE morphology ,PHOTOTHERMAL effect - Abstract
Facile preparation of multifunctional theranostic nanoplatforms with well-controlled morphology and sizes remains an attractive in the area of nanomedicine. Here, a new kind of 2D transition metal dichalcogenide, rhenium disulfide (ReS
2 ) nanosheets, with uniform sizes, strong near-infrared (NIR) light, and strong X-ray attenuation, is successfully synthesized. After surface modification with poly(ethylene glycol) (PEG), the synthesized ReS2 -PEG nanosheets are stable in various physiological solutions. In addition to their contrasts in photoacoustic imaging and X-ray computed tomography imaging because of their strong NIR light and X-ray absorptions, respectively, such ReS2 -PEG nanosheets can also be tracked under nuclear imaging after chelator-free labeling with radioisotope ions,99m Tc4+ . Efficient tumor accumulation of ReS2 -PEG nanosheets is then observed after intravenous injection into tumor-bearing mice under triple-modal imaging. The combined in vivo photothermal radiotherapy is further conducted, achieving a remarkable synergistic tumor destruction effect. Finally, no obvious toxicity of ReS2 -PEG nanosheets is observed from the treated mice within 30 d. This work suggests that such ultrathin ReS2 nanosheets with well-controlled morphology and uniform sizes may be a promising type of multifunctional theranostic agent for remotely triggered cancer combination therapy. [ABSTRACT FROM AUTHOR]- Published
- 2017
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