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1. Antibody seronegative human T-lymphotropic virus type III (HTLV-III)-infected patients with acquired immunodeficiency syndrome or related disorders.

Author

Groopman JE, Hartzband PI, Shulman L, Salahuddin SZ, Sarngadharan MG, McLane MF, Essex M, and Gallo R

Subjects
Adult, Deltaretrovirus isolation & purification, Humans, Leukopenia immunology, Lymphatic Diseases immunology, Male, Middle Aged, Sarcoma, Kaposi immunology, Thrombocytopenia immunology, Acquired Immunodeficiency Syndrome immunology, Antibodies, Viral analysis, Deltaretrovirus immunology, Retroviridae Infections immunology
Abstract

The human T-lymphotropic virus type III (HTLV-III) is the primary cause of the acquired immunodeficiency syndrome (AIDS) and related disorders (ARC). Prior studies have reported that nearly all symptomatic patients with AIDS or ARC manifest antibody to HTLV-III. This observation has engendered efforts to screen for HTLV-III, especially prior to blood donation, with assays for antibody to HTLV-III. We report the first two cases, one with AIDS and one with ARC, that are HTLV-III virus positive but antibody negative. Accurate diagnosis of HTLV-III infection in some cases may require direct virus culture or tests for antigen. In addition, lack of HTLV-III antibody may indicate an atypical clinical course of AIDS.

Published
1985

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