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Your search keyword '"Chetoui, Imene"' showing total 3 results
Start Over Author "Chetoui, Imene" Topic acrylamide
3 results on '"Chetoui, Imene"'

1. Redox status and fatty acid composition of Mactra corallina digestive gland following exposure to acrylamide.

Author

Trabelsi W, Chetoui I, Fouzai C, Bejaoui S, Rabeh I, Telahigue K, Chalghaf M, El Cafsi M, and Soudani N

Subjects
Animals, Antioxidants chemistry, Antioxidants pharmacology, Arachidonic Acid chemistry, Bivalvia chemistry, Catalase metabolism, Docosahexaenoic Acids chemistry, Eicosapentaenoic Acid analogs & derivatives, Eicosapentaenoic Acid chemistry, Glutathione metabolism, Linoleic Acid chemistry, Linoleic Acid pharmacology, Oxidation-Reduction, Oxidative Stress drug effects, Acrylamide pharmacology, Bivalvia metabolism, Digestion drug effects, Fatty Acids metabolism, Fatty Acids, Omega-3 pharmacology, Superoxide Dismutase metabolism
Abstract

Acrylamide (ACR), a ubiquitous agent, has various chemical and industrial applications, and it is found in backed or fried carbohydrate-rich food. It has been related to multiple toxicological effects, and it causes high cytotoxicity through oxidative stress. The present study aimed to investigate the potential effect of ACR toxicity administered at different concentrations (5, 10, and 20 mg/L), during 5 days, in order to evaluate the fatty acid (FA) composition and redox state in the digestive gland of Mactra corallina. The results showed, in ACR-treated clams, a significant increase in malondialdehyde, hydrogen peroxide, protein carbonyl, and metallothionein levels, as well as an alteration of the enzymatic (superoxide dismutase, glutathione peroxidase, and catalase) and non-enzymatic (reduced glutathione and ascorbic acid) antioxidant status. However, acetylcholinesterase activity was inhibited in a concentration-dependent manner. In our experiment, the n-3 (Omega-3) and n-6 (Omega-6) polyunsaturated fatty acid levels were significantly changed in all ACR-treated groups. A decrease in eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3, DHA) was observed in 10-mg/L and 20-mg/L ACR-treated groups. Nevertheless, arachidonic acid (C20:4n-6, ARA) and its precursor linoleic acid (C18:2n-6, LA) were increased. Besides oxidative stress parameters, FA composition may be an additional tool for assessing ACR contamination.

Published
2019
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2. The potential adverse effects of acrylamide on the oxidative stress response, fatty acids profile, and histopathological aspect of the Mediterranean Holothuria forskali respiratory tree.

Author

Trabelsi, Wafa, Fouzai, Chaima, Telahigue, Khaoula, Chetoui, Imene, Nechi, Salwa, Chelbi, Emna, Zrelli, Sonia, and Soudani, Nejla

Subjects
ACRYLAMIDE, FATTY acids, OMEGA-6 fatty acids, UNSATURATED fatty acids, OXIDATIVE stress, HISTOPATHOLOGY
Abstract

Acrylamide (ACR), organic compound, has been widely used owing to its broad spectrum of chemical and industrial applications. This study aims at evaluating the response of the antioxidant defense system, fatty acid composition and histopathological aspect in the respiratory trees of Holothuria forskali against ACR exposure under laboratory conditions. Holothuries were exposed to 5, 10, and 20 mg L−1 ACR concentrations for 5 days. A significant increase in n‐6 polyunsaturated fatty acids levels especially the arachidonic acid (ARA, C20:4n‐6) and its precursor linoleic acid (LA, C18:2n‐6) in ACR‐treated organisms. Regarding the n‐3 levels, eicosapentaenoic acid (EPA, C20:5n‐3) levels were increased in treated groups despite an acute decrease in docosahexaenoic acid (DHA, C22:6n‐3) levels was observed. Our results showed a significant increase in hydrogen peroxide, malondialdehyde, protein carbonyl, and metallothionein levels along with an alteration of the antioxidants status in all treated sea cucumbers. The exposure to ACR prompted the inhibition of Acetylcholinesterase activity in a concentration‐dependent manner. The histopathological aspect was marked especially with the infiltration of coelomic cells which confirms our biochemical findings. Our study provided novel insights to create a link between redox status and fatty acid composition disruptions to better understand ACR‐triggered toxicity. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Oxidative stress biomarkers in the gills of the bivalve Mactra stultorum exposed to acrylamide

Author

Trabelsi, Wafa, Fouzai, Chaima, Chetoui, Imene, Bejaoui, Safa, Telahigue, Khaoula, Rabeh, Imen, El Cafsi, Mhamed, and Soudani, Nejla

Subjects
acrylamide, exposure, Mactra stultorum, gills, antioxidant status, acetylcholinesterase, acrilamida, exposición, branquias, estado antioxidante, acetilcolinesterasa
Abstract

Acrylamide (ACR) is among the most deleterious pollutants in the environment and presents a serious risk to humans and ecosystems. The purpose of this study was to assess its effects when administered at different concentrations (5, 10 and 20 mg L–1) to evaluate antioxidant status in the gills of Mactra stultorum. Our results showed, after five days of treat­ment, an increase in malondialdehyde (MDA), lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), reduced glutathione (GSH), ascorbic acid (Vit C) and metallothionein (MDA) levels in gills of treated clams compared with controls. Moreover, an increase in superoxide dismutase (SOD) and a significant decrease in glutathione peroxidase (GPx) activities were also observed. Acrylamide induced neurotoxicity, as evidenced by the inhibition of acetylcholinesterase (AChE) activity in a dose-dependent manner. Overall, our results indicated that oxidative stress may be considered one of the mechanisms behind acrylamide toxicity in bivalves, although the subject requires more research., La acrilamida (ACR) es uno de los contaminantes más perjudiciales en el medio ambiente y presenta un grave riesgo para los seres humanos y los ecosistemas. El objetivo de este estudio es evaluar los efectos del ACR administrado a diferentes concentraciones (5, 10 y 20 mg L–1) con el fin de evaluar el estado antioxidante en las branquias de Mactra stulto­rum. Nuestros resultados mostraron, después de 5 días de tratamiento, un aumento en los niveles de malondialdehído (MDA), hidroperóxidos lipídicos (LOOH), proteínas de oxidación avanzada (AOPP), glutatión reducido (GSH), ácido ascórbico (vit C) y metalotioneínas (MTs) en las branquias de las almejas tratadas en comparación con los controles. Además, también se observó un aumento en la superóxidodismutasa (SOD) y una disminución significativa en las actividades de glutatión pero­xidasa (GPx). La acrilamida indujo neurotoxicidad como lo demuestra la inhibición de la actividad de la acetilcolinesterasa (AChE) de una manera dependiente de la dosis. En general, nuestros resultados indicaron que el estrés oxidativo puede con­siderarse como uno de los mecanismos detrás de la toxicidad por ACR en los bivalvos, aunque el tópico debería beneficiarse de más investigaciones.

Published
2020
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