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Copyright of Bulletin of Botanical Research is the property of Bulletin of Botanical Research Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study aimed to determine the chemical profile, cell‐based safety, antioxidant properties, antibacterial effect, and mode of action of Lactobacillus helveticus postbiotics (LHPs) against Escherichia coli O157:H7 and multidrug‐resistant Staphylococcus aureus. LHPs exhibited significant radical scavenging activity (83.59% ± 4.21% for Hydroxyl RSA; 98.33% ± 2.47% for DPPH; and 21.67% ± 2.79% for linoleic acid peroxidation inhibitory), and antibacterial action toward MDR S. aureus (inhibition zone (IZ): 32.76 mm; minimum inhibitory concentration (MIC): 36.00 μg/mL; minimum bactericidal concentration (MBC): 45.00 μg/mL; minimal effective concentration (MEC): 25 mg/mL for whole milk, and 30 mg/mL for ground meat) and E. coli O157:H7 (IZ: 25.63 mm; MIC: 60.00 μg/mL; MBC: 90.00 μg/mL: MEC: 35 mg/mL for whole milk, and 45 mg/mL for ground meat) (p < 0.05). As an antimicrobial mode of action, significant alterations in the bacterial surface charge, membrane integrity, biofilm generation, auto‐aggregation ability, and swimming/sliding motility, along with the subsequent intracellular content leakage from MDR S. aureus and E. coli O157:H7, were detected after treatment with LHPs (p < 0.05). LHPs exerted a promoting influence on MV‐4‐11 macrophage cell viability, leading to a considerable increase in the functions of SOD and GSH‐Px in these cells. As well, LHPs caused a reduction in the production of NO and a drop in ROS levels (p < 0.05). Therefore, LHPs are a promising approach against MDR S. aureus and E. coli O157:H7 proliferations and have the capacity to be used in the food sector to combat safety issues caused by pathogenic microbes. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AbstractThe formation of ice crystals poses a significant challenge to food quality and safety during the food freezing process. Peptide-based cryoprotectants offer an innovative solution for the long-term preservation of frozen foods. This review provides a comprehensive overview of the current state of research on peptide-based cryoprotectants, encompassing sources, acquisition methods, functional properties, structure-activity relationships, action mechanisms, and applications. Specifically, peptide-based cryoprotectants can be derived from both terrestrial and aquatic organisms. They are usually prepared by using techniques such as solvent extraction, enzymatic hydrolysis, chemical synthesis, and heterologous biosynthesis. Moreover, they can specifically adsorb onto the surface of ice crystals, reducing the freezing point and thereby effectively inhibiting the growth of ice crystals. Additionally, their performance can be influenced by structures such as amino acid composition, molecular weight, and peptide sequence. Furthermore, future research directions are proposed, including rapid discovery techniques, efficient large-scale production methods, and safety assessments for peptide-based cryoprotectants. These research initiatives are of significant importance for advancing the broad application of peptide-based cryoprotectants in the food industry. [ABSTRACT FROM AUTHOR]

Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) is derived from the dried pseudobulb of the orchid family plants Cremastra appendiculata (D.Don) Makino, Pleione bulbocodioides (Franch.) Rolfe, or Pleione yunnanensis Rolfe, and has the properties of clearing heat, detoxification, resolving phlegm, and dispersing nodules. It is frequently used for the treatment of various malignant tumors in clinical practice, especially lung cancer. CPPP is divided into two commercial specifications in the market, Maocigu (MCG) and Bingqiuzi (BQZ). However, owing to a lack of appropriate research strategies, the active ingredients and molecular mechanisms involved have not yet been clarified. This study intended to discover the combination of effective anti-lung-cancer ingredients in CPPP and explore their potential mechanisms of action. In this study, UHPLC-MS fingerprints of MCG and BQZ were established separately. Inhibitory effects on the proliferative viability and migratory ability of A459 and H1299 cells were evaluated as pharmacodynamic indicators. GRA and BCA were used to determine spectrum–effect relationships. Next, the identification and analysis of components of drug-containing serum were performed using UHPLC-Q-Exactive Orbitrap MS. Then, the results of the two analyses were combined to jointly screen out the anti-lung-cancer candidate active monomers of CPPP, and their in vitro activities were verified. Afterward, all effective ingredient combinations of MCG (MCGC) and BQZ (BQZC) were prepared according to their contents in the original medicinal materials. Their anti-lung-cancer activities in vitro and in vivo were compared and verified. Finally, we used the human lung cancer cell line A549 and the Lewis tumor xenograft model to investigate how BQZC would influence autophagy and apoptosis processes and the mechanisms involved. Overall, 11 predominant anti-lung-cancer active ingredients from CPPP were screened. Next, MCGC and BQZC were prepared according to their contents in the original medicinal materials, respectively, and their anti-tumor effects were equivalent to those of the original materials in vitro and in vivo. We found that BQZC could inhibit lung cancer cell growth and induce protective autophagy and apoptosis in lung cancer cells by activating the AMPK–mTOR–ULK1/BMF signaling pathway. These results provide important evidence for the clinical application and deep development of CPPP against tumors. [ABSTRACT FROM AUTHOR]

Urtica species is an angiosperm plant in the Urticaceae family. It serves as a traditional food and medicinal herb, possessing high nutritional value and various bioactive compounds, including polysaccharides, flavonoids, and polyphenolic compounds. In the realm of animal feeds, Urtica spp. can replace traditional protein feed sources and high-quality forage, thereby reducing feed costs. Moreover, Urtica spp. extract exhibits antioxidant and anti-inflammatory properties and boosts immune regulation. Hence, Urtica spp. plays a beneficial role in enhancing animal performance and improving their immune function. Recently, with the development of sustainable farming techniques, the demand for feed additives that prioritize safety, the absence of drug residues, and environmental friendliness have grown. Consequently, Urtica spp. and its extracts have received widespread attention in animal production. This article summarizes the biological functions of Urtica spp. and its application in animal husbandry while also outlining future prospects for its application. It will provide a scientific basis and reference point for the application of Urtica spp. in animal health and breeding. [ABSTRACT FROM AUTHOR]

Copyright of Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas is the property of Universidad de Santiago de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Manuela Gómez-Gaviria, Luisa M Contreras-López, Julieta I Aguilera-Domínguez, Héctor M Mora-Montes Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, Gto, MéxicoCorrespondence: Héctor M Mora-Montes, Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Col. Noria Alta, C.P, Guanajuato, Gto, 36050, México, Tel +52 473-7320006 Ext. 8193, Fax +52 473-7320006 Ext. 8153, Email hmora@ugto.mxAbstract: Fungal infections represent a worldwide concern for public health, due to their prevalence and significant increase in cases each year. Among the most frequent mycoses are those caused by members of the genera Candida, Cryptococcus, Aspergillus, Histoplasma, Pneumocystis, Mucor, and Sporothrix, which have been treated for years with conventional antifungal drugs, such as flucytosine, azoles, polyenes, and echinocandins. However, these microorganisms have acquired the ability to evade the mechanisms of action of these drugs, thus hindering their treatment. Among the most common evasion mechanisms are alterations in sterol biosynthesis, modifications of drug transport through the cell wall and membrane, alterations of drug targets, phenotypic plasticity, horizontal gene transfer, and chromosomal aneuploidies. Taking into account these problems, some research groups have sought new therapeutic alternatives based on drug repositioning. Through repositioning, it is possible to use existing pharmacological compounds for which their mechanism of action is already established for other diseases, and thus exploit their potential antifungal activity. The advantage offered by these drugs is that they may be less prone to resistance. In this article, a comprehensive review was carried out to highlight the most relevant repositioning drugs to treat fungal infections. These include antibiotics, antivirals, anthelmintics, statins, and anti-inflammatory drugs.Keywords: action mechanisms, antifungal resistance, clinical pathogens, repositioning, new treatments

In the context of global climate change, improving agricultural carbon productivity is an important channel to cope with climate change, reduce agricultural carbon emissions and maintain agricultural growth. For a long time, agricultural development in China mainly depends on the government's fiscal expenditure. However, does fiscal support helps to promote carbon productivity of agriculture? This question remains to be answered. Using a set of panel data covering 31 provinces and cities from 2003 to 2019, this study empirically explores the impact of agricultural fiscal support on agricultural carbon productivity in China. Benchmark regression results indicate that after controlling other influential factors, regional fiscal expenditure on agricultural has a significantly positive impact on agricultural carbon productivity. In addition, the promotion impacts of fiscal support on agricultural technological innovation and scale operation efficiency are two effective channels by which to help promote agricultural carbon productivity. By using a panel threshold regression model, we find that there exists a nonlinear relationship between fiscal support and agricultural carbon productivity. The input of agricultural machinery and chemical fertilizer are two threshold variables. Further, this causal linkage between fiscal support and agricultural carbon productivity exists differences because of the different levels of agricultural carbon productivity and regions. Our research provides Chinese theoretical basis and practical reference for improvement of agricultural carbon productivity from the perspective of fiscal expenditure. [ABSTRACT FROM AUTHOR]

Zinc‐ion batteries (ZIBs) have become a global research hotspot in recent years due to their eco‐friendliness, safety, abundant resources, and low cost. However, some significant challenges seriously affect their overall performance, thus hindering their further development and practical applications. Recently, multifunctional and adjustable 2D carbides and nitrides (MXenes) are extensively used for the modification of ZIBs, and fruitful achievements are achieved. In order to make a systematic understanding of these studies, it is highly desirable to provide an overview of MXenes based on their modification methods and action mechanisms. In this review, a basic introduction to ZIBs and MXenes is presented and the main modification approaches of MXenes in solving the issues of ZIBs are discussed in detail, including activation and composite strategies of the cathode, interface engineering, structural optimization, and zinc metal‐free anode strategy of the anode, solid‐state strategy of the electrolyte, and functionalized strategy of the separator. Importantly, the functions and related mechanisms of MXenes in various components of ZIBs are analyzed in depth. Finally, the pathways for MXenes in solving the issues of ZIBs are summarized, and their future directions are prospected. [ABSTRACT FROM AUTHOR]

There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both in vitro and in vivo, as well as clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, and health advantages. Dietary polyphenols have demonstrated the potential to prevent many health problems, including obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, and neurological diseases. In this paper, the protective effects of polyphenols and the mechanisms behind them are investigated in detail, citing the most recent available literature. This review aims to provide a comprehensive overview of the current knowledge on the role of polyphenols in preventing and managing chronic diseases. The cited publications are derived from in vitro, in vivo, and human-based studies and clinical trials. A more complete understanding of these naturally occurring metabolites will pave the way for the development of novel polyphenol-rich diet and drug development programs. This, in turn, provides further evidence of their health benefits. [ABSTRACT FROM AUTHOR]

Abstract The related studies of probiotics‐based functional foods have recently attracted increasing interests in developing new types of oral administration systems. Probiotics has various biological functions, including increasing adsorption ability of nutrients, competitively rejecting pathogenic organisms, and regulating the immune system. It is well known that probiotics cannot be worked until their colonies reach the intestine alive, as well as the amount reaches 106–107 colony‐forming units/g at the end of product's shelf life. However, the delivery of probiotics to the colon through oral administration is always challenging due to weak viability under exposure to harsh conditions in the presence of ions and small molecules from the upper gastrointestinal tract. Moreover, the low viability of the probiotics due to the lack of resistance to the acidity of food matrices, high temperature during food processing, and oxygen changes during storage also limit the applications of probiotics in food products. Therefore, encapsulation of probiotics could particularly protect the probiotics from degradation and inactivation, resulting in enhanced viability during the transition from consumption to digestion in the gut. Emulsion cross‐linking, complex coacervation, microcapsules, spray drying, layer‐by‐layer self‐assembly, electrospinning, hydrogel, and other methods are used to encapsulate probiotics. Herein, this review mainly highlights the gut health functions and encapsulation techniques of probiotics, followed by the current challenges and future development prospects.

The permeability of shale controls gas transport in shale gas reservoirs. The shale has a complex pore structure at the nanoscale and its permeability is affected by multiple transport and action mechanisms. In this study, a 3D fractal model for predicting the apparent gas permeability of shale matrix is presented, accounting for the effects of the transport mechanisms (bulk gas transport and adsorption gas diffusion) and action mechanisms (gas adsorption, real gas properties, water film, stress dependence, and total organic carbon (TOC) content). The proposed model is validated with the published experimental data. A series of sensitivity analyses are performed to investigate the influence of fractal characteristics and action mechanisms on the apparent permeability caused by each transport mechanism. The results show that the real gas properties, water film, and stress dependence cause different effects on the total apparent permeability of shale under different fractal characteristics. The maximum pore diameter is inversely proportional to the effects of these action mechanisms, and the porosity is positively proportional to the effects of real gas properties and water film but inversely proportional to the effects of stress dependence. An increase in TOC content can cause an improvement in the total apparent permeability. Furthermore, the effects of action mechanisms on the apparent permeability caused by different transport mechanisms are differently affected by the fractal characteristics. Changes in fractal characteristics mainly affect the apparent permeability caused by slip flow in the real gas effect, slip flow and Knudsen diffusion in the water film effect, and all transport mechanisms in the stress dependence effect. [ABSTRACT FROM AUTHOR]

Probiotics, living microorganisms with demonstrated health benefits when administered in sufficient quantities, have a rich history as dietary supplements to benefit human health. Recently, understanding of their mechanisms in the gastrointestinal tract has prompted exploration of probiotics in treating human diseases. However, the effective and precise delivery of probiotics remains a significant challenge in therapeutic applications. Here, we review the mechanisms of action of probiotics in human health and the most advanced strategies for efficient probiotic delivery. We also discuss the potential applications of engineered probiotics in disease treatment. This review contributes insights into the evolving landscape of probiotic research for therapeutic applications. [ABSTRACT FROM AUTHOR]

Copyright of Prospectiva is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Plant resistance to drought stress is a parameter that should be studied with more emphasis in the search for higher agricultural yields. In this scenario, research within breeding programs should be directed toward specific mechanisms of action and important agricultural crops in worldwide agribusiness. From this perspective, this study carried out a bibliographic investigation regarding the advances in genetic improvement aimed at drought stress in crops using a hybrid model of analysis of scientific articles. The analysis employed bibliometric parameters for qualitative and quantitative discussion of scientific production and the methodological process of systematic review for the synthesis of the results obtained. The work was divided into four stages: the search for articles in databases, meta-analysis, bibliometric analysis, and systematic analysis. Scientific articles were searched for on the Scopus, Scielo, and Web of Science databases within a 20-year timeframe. Most authors and institutions were from Asian countries, demonstrating the need for global expansion of research on the subject. With regard to the co-occurrence networks between the keywords used in the search, a focus was observed on the following terms: drought resistance, drought stress; drought, and drought tolerance. Evidently, the primary mechanism of tolerance or even resistance studied in breeding programs is associated with the expression of genes and genetically modified organisms that confer resistance to plants. Also, the crops addressed in the research retrieved are highly diverse. [ABSTRACT FROM AUTHOR]

Rice with a high resistant starch (RS) content is one the most commonly used, effective, and safe functional foods, which can be used to prevent diabetes and its related complications in humans. Based on the health benefits (highest to lowest), the types of RS can be categorized as follows: RS1> RS3> RS5> RS4> RS2. Here, we discuss the biosynthesis and mechanism of action [processing changes, biochemistry, and glycemic index (GI)] of the five RS types present in rice as well as their potential of preventing diabetes-related diseases, based on reports published from 2004 to 2021 in PubMed, CNKI, and ISI Web of Science databases. High-RS rice has gained considerable interest owing to the advantages it offers as a staple food product and its potential for controlling appetite with satiety, lowering glucose levels in the stomach and small intestine, and increasing the short-chain fatty acid content in the large intestine, which helps combat metabolic syndrome by controlling gluconeogenesis, promoting glycogenesis, maintaining glucose and lipid homeostasis, and improving pancreatic function. Rice is an important source of RS (>3%, GI<55) and can help prevent diabetes. However, certain types of rice have a high GI (>85), which may induce metabolic syndrome. The RS content of rice ranges from 0.1% to 25.4% and the GI ranges from 44 to 132, which has many factors relating in the white rice. In this review, we discuss the diversity in RS content based on the biosynthetic mechanism and the mechanism of action of high-RS rice in diabetes. We also discuss potential limitations of rice breeding programs and the methods that can be used to ensure the availability of effective, yet palatable, high-RS rice. [ABSTRACT FROM AUTHOR]

Multiresistant pathogens pose a serious threat to human health. The genus Candida is one class of human pathogenic yeasts responsible for infections affecting healthy and immunocompromised patients. In this context, plant essential oils emerged as a future natural alternative to control the diseases caused by these pathogens. Based on that, the present study aimed to evaluate the antimicrobial potential of essential oil from C. pluriglandulosus and understand the mechanism of action. Here, it highlighted antimicrobial activity and the mechanisms of action of the essential oil extracted from C. pluriglandulosus Carn.-Torres & Riina (CpEO) leaves on human pathogenic microorganisms in planktonic and biofilm lifestyles. In addition, for the first time, the oil composition was revealed by GC-MS analysis and the toxicity to human red blood cells (HRBC). Twenty-six chemical compounds were identified in CpEO, elemicin, bicyclogermacrene, caryophyllene, brevifolin, and 2,4,6-trimethoxy-styrene. Through hemolytic assay, it was shown that CpEO has no toxicity to human RBCs. At the concentration of 50 μg mL−1, CpEO did not show great antibacterial potential. However, promising data were found for C. krusei and C. parapsilosis inhibiting by 89.3% and 80.7% of planktonic cell growth and 83.5% and 77.9% the biofilm formation, respectively. Furthermore, the mechanisms of action CpEO were elucidated by fluorescence. Scanning electron microscopy revealed damage to the cell membrane and pore formation, ROS overproduction, and induction of apoptosis in candida cells. Our results reinforce the potential of CpEO as an effective alternative molecule of pharmaceutical interest. [ABSTRACT FROM AUTHOR]

Heavy metals and metalloids (HMs) are environmental pollutants, most notably cadmium, lead, arsenic, mercury, and chromium. When HMs accumulate to toxic levels in agricultural soils, these non-biodegradable elements adversely affect crop health and productivity. The toxicity of HMs on crops depends upon factors including crop type, growth condition, and developmental stage; nature of toxicity of the specific elements involved; soil physical and chemical properties; occurrence and bioavailability of HM ions in the soil solution; and soil rhizosphere chemistry. HMs can disrupt the normal structure and function of cellular components and impede various metabolic and developmental processes. This review evaluates: (1) HM contamination in arable lands through agricultural practices, particularly due to chemical fertilizers, pesticides, livestock manures and compost, sewage-sludge-based biosolids, and irrigation; (2) factors affecting the bioavailability of HM elements in the soil solution, and their absorption, translocation, and bioaccumulation in crop plants; (3) mechanisms by which HM elements directly interfere with the physiological, biochemical, and molecular processes in plants, with particular emphasis on the generation of oxidative stress, the inhibition of photosynthetic phosphorylation, enzyme/protein inactivation, genetic modifications, and hormonal deregulation, and indirectly through the inhibition of soil microbial growth, proliferation, and diversity; and (4) visual symptoms of highly toxic non-essential HM elements in plants, with an emphasis on crop plants. Finally, suggestions and recommendations are made to minimize crop losses from suspected HM contamination in agricultural soils. [ABSTRACT FROM AUTHOR]

Pathogenic bacterium Legionella pneumophila, the causative agent of Legionnaires’ disease, secretes hundreds of effectors into host cells that subvert cell pathways during pathogenesis. The Lgt family effectors, containing Lgt1, Lgt2, and Lgt3, from L. pneumophila are glycosyltransferase that shut down protein synthesis in human cells by specific glycosylation of a serine residue in the eukaryotic elongation factor 1 A (eEF1A), but the action mechanism remains poorly understood. Herein, the structural basis of the action mechanism is unveiled. Lgt family effectors catalyze the transfer of glucose moiety of UDP‐glucose in a conserved retaining mechanism, but exhibit different substrate recognition mechanisms. Lgt2 bears the positive‐charged catalytic cleft to interact with the negatively charged patches in helices α2 and α3 of eEF1A; instead, Lgt1 employs a negatively charged surface of E445 and E446, which are proposed to interact with residue Lys51 in eEF1A. And Lgt family effectors inhibit host unfolded protein response by shutting down host protein synthesis. These results provide a structural basis of action mechanism of glycosyltransferase and highlight the role of glycosyltransferase in Legionella's lifecycle.

Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand the potential effects of the Croton genus on several diseases. It has been revealed that these terpenoid-rich species traditionally used to treat gastrointestinal diseases, heal wounds, and relieve pain have a wide range of therapeutic effects; however, those used to treat diabetes, as well as their action mechanisms, have not been reviewed so far. Therefore, the main objective of this review was to compile all Croton species that have shown pharmacological effects against diabetes and describe their action mechanisms. Through a search of the literature, 17 species with hypoglycemic, antihyperglycemic, antilipidemic, antihypertensive, antioxidant, and anti-inflammatory effects were found. Among the mechanisms by which they exerted these effects were the inhibition of α-glucosidases, the promotion of insulin secretion, and the increase in glucose uptake. Interestingly, it was found that some of them may have antihyperglycemic properties, although there were no ethnopharmacological reports that support their traditional use. Moreover, others only presented studies on their hypoglycemic effect in fasting, so further works are encouraged to describe the mechanisms involved in lowering fasting blood glucose levels, such as hepatic glucose production, especially for C. cajucara, C. cuneatus, C. gratissimus var. gratissimus, C. guatemalensis, and C. membranaceus. It is expected that this review contributes to the plant science knowledge of the genus, and it can be used in future references on the identification and development of new molecules/phytomedicines that help in the treatment of diabetes. [ABSTRACT FROM AUTHOR]

• Effects of environmental factors and dynamic loads on UHPC are reviewed. • Theoretical models are summarized to reveal underlying destruction mechanisms. • Additives enhance durability and dynamic mechanical properties of UHPC. • UHPC is an ideal engineering material for applications in OWTs. Ultra-high performance concrete (UHPC), characterized by its high strength and toughness as well as durability, provides a promising solution for the construction of offshore wind towers (OWTs). This paper comprehensively reviews the durability and the dynamic mechanical properties of UHPC for OWTs under the impacts of the marine environment. Furthermore, the modifying effects of additives, including supplementary cementitious materials (SCMs) and reinforcing fibers, as well as nanofillers on UHPC are explored. Overall, UHPC possesses a dense microstructure that impedes the intrusion of harmful substances, and owing to the incorporation of additives, UHPC exhibits outstanding dynamic mechanical properties, making it an ideal material for applications in OWTs subjected to vibration fatigue and dynamic impact loads. Incorporating SCMs into UHPC can improve the durability and environmental benefits while maintaining similar dynamic mechanical properties concurrently. Nanofillers can serve as a beneficial supplement to steel fibers providing improved durability and dynamic mechanical properties by endowing UHPC dense microstructure and high system energy. Various models of marine environmental and loading actions on UHPC, examining ion transport, matrix degradation, and constitutive models, are concluded to gain insight into the underlying destructive mechanisms. These underlying mechanisms and the theoretical models further deepen the understanding of the service performance of UHPC in marine environments, thus providing the design guidance for the potential applications of UHPC in OWTs. [ABSTRACT FROM AUTHOR]

Context: The antagonistic capacity of Trichoderma harzianum Rifai against fungal pathogen Sclerotium oryzae (Catt.) strain A-34, and the action mechanisms against the fungal pathogen of Sclerotium oryzae (Catt.), which caused crop losses. Aim: To evaluate the antagonistic capacity of Trichoderma harzianum Rifai against the fungal pathogen Sclerotium oryzae (Catt.). Methods: The concentration of spores/ml-1, the viability and mycelia growth inhibition of the pathogen, and the antagonistic capacity of Trichoderma harzianum, through the action mechanisms. The results were processed using SPSS, version 22.0, for Windows, and Tukey’s test results had a 0.05% probability. A completely randomized experimental design was used for each pathogenic fungus. Results: No antibiosis was observed at 24 hours because the antagonistic did not inhibit pathogen growth; at 72 hours, there was hyphal interaction between S. oryzae and T. harzianum, and there was no mycoparasitism by the antagonist. S. oryzae grew more than the antagonistic at 96 hours, and at 120 hours, the antagonistic grew more than S. oryzae; therefore, no antagonistic or hyper-parasitic activity were observed in the pathogen. Conclusions: The antagonist did not affect the mycelial growth of S. oryzae during the dual challenge. Likewise, T. harzianum (strain A-34) showed no antagonistic activity against Sclerotium oryzae, with a negative inhibition percent of Radial Growth, seen through antibiosis and the action mechanisms.

Cardiovascular diseases are the leading cause of death in the world. High cholesterol is one of the biggest risk factors for these diseases, so the need for natural sources that can lower cholesterol has been of interest since the medications used often cause adverse effects. Hypocholesterolemic capacity has been evaluated in microorganisms, mainly probiotics, which have been extensively studied, and a positive effect has been observed in the reduction of cholesterol, which is enhanced with the use of dietary fibers or prebiotics. So, the objective of this review is to gather information on these studies including proposed mechanisms. [ABSTRACT FROM AUTHOR]

Copyright of Investigaciones Feministas is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Chicken and seafood are highly perishable owing to the higher moisture and unsaturated fatty acids content which make them more prone to oxidation and microbial growth. In order to preserve the nutritional quality and extend the shelf-life of such products, consumers now prefer chemical-free alternatives, such as lactic acid bacteria (LAB) and essential oils (EOs), which exert a bio-preservative effect as antimicrobial and antioxidant compounds. This review will provide in-depth information about the properties and main mechanisms of oxidation and microbial spoilage in chicken and seafood. Furthermore, the basic chemistry and mode of action of LAB and EOs will be discussed to shed light on their successful application in chicken and seafood products. Metabolites of LAB and EOs, either alone or in combination, inhibit or retard lipid oxidation and microbial growth by virtue of their principal constituents and bioactive compounds including phenolic compounds and organic acids (lactic acid, propionic acid, and acetic acid) and others. Therefore, the application of LAB and EOs is widely recognized to extend the shelf-life of chicken and seafood products naturally without altering their functional and physicochemical properties. However, the incorporation of any of these agents requires the optimization steps necessary to avoid undesirable sensory changes. In addition, toxicity risks associated with EOs also demand the regularization of an optimum dose for their inclusion in the products. [ABSTRACT FROM AUTHOR]

Chicken and seafood are highly perishable owing to the higher moisture and unsaturated fatty acids content which make them more prone to oxidation and microbial growth. In order to preserve the nutritional quality and extend the shelf-life of such products, consumers now prefer chemical-free alternatives, such as lactic acid bacteria (LAB) and essential oils (EOs), which exert a bio-preservative effect as antimicrobial and antioxidant compounds. This review will provide in-depth information about the properties and main mechanisms of oxidation and microbial spoilage in chicken and seafood. Furthermore, the basic chemistry and mode of action of LAB and EOs will be discussed to shed light on their successful application in chicken and seafood products. Metabolites of LAB and EOs, either alone or in combination, inhibit or retard lipid oxidation and microbial growth by virtue of their principal constituents and bioactive compounds including phenolic compounds and organic acids (lactic acid, propionic acid, and acetic acid) and others. Therefore, the application of LAB and EOs is widely recognized to extend the shelf-life of chicken and seafood products naturally without altering their functional and physicochemical properties. However, the incorporation of any of these agents requires the optimization steps necessary to avoid undesirable sensory changes. In addition, toxicity risks associated with EOs also demand the regularization of an optimum dose for their inclusion in the products.

Plant resistance to drought stress is a parameter that should be studied with more emphasis in the search for higher agricultural yields. In this scenario, research within breeding programs should be directed toward specific mechanisms of action and important agricultural crops in worldwide agribusiness. From this perspective, this study carried out a bibliographic investigation regarding the advances in genetic improvement aimed at drought stress in crops using a hybrid model of analysis of scientific articles. The analysis employed bibliometric parameters for qualitative and quantitative discussion of scientific production and the methodological process of systematic review for the synthesis of the results obtained. The work was divided into four stages: the search for articles in databases, meta-analysis, bibliometric analysis, and systematic analysis. Scientific articles were searched for on the Scopus, Scielo, and Web of Science databases within a 20-year timeframe. Most authors and institutions were from Asian countries, demonstrating the need for global expansion of research on the subject. With regard to the co-occurrence networks between the keywords used in the search, a focus was observed on the following terms: drought resistance, drought stress; drought, and drought tolerance. Evidently, the primary mechanism of tolerance or even resistance studied in breeding programs is associated with the expression of genes and genetically modified organisms that confer resistance to plants. Also, the crops addressed in the research retrieved are highly diverse.

Germinated legumes are sources of bioactive compounds, such as phenolic compounds (PC), with beneficial effects, one and the most relevant is anticancer activity (colon, breast, among others). Colon cancer is a severe worldwide public health concern, development of the sporadic type is mainly related to eating habits and lifestyle; but also, this type is the most frequent. Legumes have been the main sources of PC and their action on colon cancer has been studied already. Sprouting process enhances the production and types of PC, which have shown biological activities against colon cancer. However, the molecular mechanisms by which PC from germinated legumes can act beneficially on colon cancer are still unknown. This review retrieves evidence that germinated legumes improve the amount and types of PC with anti-colon cancer activity. [ABSTRACT FROM AUTHOR]

Accurate examination of poverty-causing factors and their mechanisms of poverty-stricken farmer households from a fine scale is conducive to policy implementation and long-term effective poverty reduction. The spatial effects in most previous studies are not fully considered, resulting in less reliability of detection results. Therefore, by fully considering background effects and spatial–temporal effects, this study designs a hierarchical spatial–temporal regressive model (HSTRM) to accurately identify the factors as well as mechanisms that cause poverty more reasonably. The empirical study of Fugong County, Yunnan Province, China, shows that: (1) There has been a certain degree of spatial effects in the study area over the years; therefore, spatial effects should be considered. (2) The poverty degree of farmer households in the study area is affected by individual factors and background factors. Therefore, poverty-causing factors should be observed at different levels. (3) Poverty-causing factors feature different action mechanisms. The influence of the village-level factors on poverty is greater than that of the household level. In addition, the village-level factors have a certain impact on the contribution of household-level factors to poverty. This study offers technical support and policy guidance for sustainable poverty reduction and development of poor farmer households. [ABSTRACT FROM AUTHOR]

Botrytis cinerea is the phytopathogenic fungus responsible for the gray mold disease that affects crops worldwide. Essential oils (EOs) have emerged as a sustainable tool to reduce the adverse impact of synthetic fungicides. Nevertheless, the scarce information about the physiological mechanism action and the limitations to applying EOs has restricted its use. This study focused on elucidating the physiological action mechanisms and prospection of lipid nanoparticles to apply EO of Mentha piperita. The results showed that the EO of M. piperita at 500, 700, and 900 μL L−1 inhibited the mycelial growth at 100 %. The inhibition of spore germination of B. cinerea reached 31.43 % at 900 μL L−1. The EO of M. piperita decreased the dry weight and increased pH, electrical conductivity, and cellular material absorbing OD 260 nm of cultures of B. cinerea. The fluorescence technique revealed that EO reduced hyphae width, mitochondrial activity, and viability, and increased ROS production. The formulation of EO of M. piperita loaded- solid lipid nanoparticles (SLN) at 500, 700, and 900 μL L−1 had particle size ∼ 200 nm, polydispersity index < 0.2, and stability. Also, the thermogravimetric analysis indicated that the EO of M. piperita -loaded SLN has great thermal stability at 50 °C. EO of M. piperita -loaded SLN reduced the mycelial growth of B. cinerea by 70 %, while SLN formulation (without EO) reached 42 % inhibition. These results supported that EO of M. piperita -loaded SLN is a sustainable tool for reducing the disease produced by B. cinerea. • Essential oil (EO) of Mentha piperita decrease mycelia growth of Botrytis cinerea. • EO of M. piperita promotes the release of cell constituents of B. cinerea. • EO of M. piperita alters fluidity of cell membrane and mitochondrial activity. • Solid lipid nanoparticles containing EO of M. piperita has antifungal activity. [ABSTRACT FROM AUTHOR]

Type 2 diabetes mellitus (T2DM) has become a universal and chronic global public health concern and causes multiple complex complications. In order to meet the rapidly growing demand for T2DM treatment, increased research has been focused on hypoglycemic drugs. Cyclocarya paliurus (Batal.) Iljinsk is the only living species of the genus Cyclocarya Iljinskaja, whose leaves have been extensively used as a functional tea to treat obesity and diabetes in China. An enormous amount of very recent pharmacological research on the leaves of C. paliurus has demonstrated that they carry out numerous biological activities, such as hypoglycemic, anti-inflammatory, and intestinal microbiota regulation. Multiple in vitro and in vivo studies have also shown that the extracts of C. paliurus leaves are innocuous and safe. This study aims to provide an up-to-date review of the botany, traditional uses, phytochemistry, pharmacological effects against diabetes, toxicology, and clinical studies of C. paliurus leaves, in hopes of promoting a better understanding of their role in the prevention and treatment of T2DM. [ABSTRACT FROM AUTHOR]

Psychological Capital has been proposed as one of the main bases of the current competitive advantage of any organization; therefore, many studies have assessed the effects of this variable on different work environments. However, to date, no study has addressed systematically the existing research on PsyCap as a mediating and moderating variable in the workplace. The aim of this paper is to respond to the need for reconstruction and reinforcement of the theory surrounding PsyCap and to shed light on the factors that seem to influence the PsyCap levels. Studies included in the Web of Science (WOS) and PsycINFO databases from 2004 to 2020 are reviewed. The results show the importance of PsyCap within the fields of creativity, psychological health, performance, job satisfaction, organizational climate, leadership and other emerging issues. Furthermore, we propose a new classification to integrate all these antecedents of PsyCap, which has important theoretical and practical implications. [ABSTRACT FROM AUTHOR]

Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand the potential effects of the Croton genus on several diseases. It has been revealed that these terpenoid-rich species traditionally used to treat gastrointestinal diseases, heal wounds, and relieve pain have a wide range of therapeutic effects; however, those used to treat diabetes, as well as their action mechanisms, have not been reviewed so far. Therefore, the main objective of this review was to compile all Croton species that have shown pharmacological effects against diabetes and describe their action mechanisms. Through a search of the literature, 17 species with hypoglycemic, antihyperglycemic, antilipidemic, antihypertensive, antioxidant, and anti-inflammatory effects were found. Among the mechanisms by which they exerted these effects were the inhibition of α-glucosidases, the promotion of insulin secretion, and the increase in glucose uptake. Interestingly, it was found that some of them may have antihyperglycemic properties, although there were no ethnopharmacological reports that support their traditional use. Moreover, others only presented studies on their hypoglycemic effect in fasting, so further works are encouraged to describe the mechanisms involved in lowering fasting blood glucose levels, such as hepatic glucose production, especially for C. cajucara, C. cuneatus, C. gratissimus var. gratissimus, C. guatemalensis, and C. membranaceus. It is expected that this review contributes to the plant science knowledge of the genus, and it can be used in future references on the identification and development of new molecules/phytomedicines that help in the treatment of diabetes.

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Accurate examination of poverty-causing factors and their mechanisms of poverty-stricken farmer households from a fine scale is conducive to policy implementation and long-term effective poverty reduction. The spatial effects in most previous studies are not fully considered, resulting in less reliability of detection results. Therefore, by fully considering background effects and spatial–temporal effects, this study designs a hierarchical spatial–temporal regressive model (HSTRM) to accurately identify the factors as well as mechanisms that cause poverty more reasonably. The empirical study of Fugong County, Yunnan Province, China, shows that: (1) There has been a certain degree of spatial effects in the study area over the years; therefore, spatial effects should be considered. (2) The poverty degree of farmer households in the study area is affected by individual factors and background factors. Therefore, poverty-causing factors should be observed at different levels. (3) Poverty-causing factors feature different action mechanisms. The influence of the village-level factors on poverty is greater than that of the household level. In addition, the village-level factors have a certain impact on the contribution of household-level factors to poverty. This study offers technical support and policy guidance for sustainable poverty reduction and development of poor farmer households.

This study employed a systems pharmacology approach to identify the active compounds and action mechanisms of Wenxin Keli for arrhythmia treatment. Sixty-eight components identified in vivo and in vitro by UPLC/Q-TOF-MS were considered the potential active components of Wenxin Keli. Network pharmacology further revealed 33 key targets and 75 KEGG pathways as possible pathways and targets involved in WK-mediated treatment, with the CaMKII/CNCA1C/Ca2+ pathway being the most significantly affected. This finding was validated using an AC-induced rat arrhythmias model. Pretreatment with Wenxin Keli reduced the malignant arrhythmias and shortened RR, PR, and the QT interval. Wenxin Keli exerted some antiarrhythmic effects by inhibiting p-CaMKII and intracellular Ca2+ transients and overexpressing CNCA1C. Thus, suppressing SR Ca2+ release and maintaining intracellular Ca2+ balance may be the primary mechanism of Wenxin Keli against arrhythmia. In view of the significance of CaMKII and NCX identified in this experiment, we suggest that CaMKII and NCX are essential targets for treating arrhythmias.

This study employed a systems pharmacology approach to identify the active compounds and action mechanisms of Wenxin Keli for arrhythmia treatment. Sixty-eight components identified in vivo and in vitro by UPLC/Q-TOF-MS were considered the potential active components of Wenxin Keli. Network pharmacology further revealed 33 key targets and 75 KEGG pathways as possible pathways and targets involved in WK-mediated treatment, with the CaMKII/CNCA1C/Ca2+ pathway being the most significantly affected. This finding was validated using an AC-induced rat arrhythmias model. Pretreatment with Wenxin Keli reduced the malignant arrhythmias and shortened RR, PR, and the QT interval. Wenxin Keli exerted some antiarrhythmic effects by inhibiting p-CaMKII and intracellular Ca2+ transients and overexpressing CNCA1C. Thus, suppressing SR Ca2+ release and maintaining intracellular Ca2+ balance may be the primary mechanism of Wenxin Keli against arrhythmia. In view of the significance of CaMKII and NCX identified in this experiment, we suggest that CaMKII and NCX are essential targets for treating arrhythmias. [ABSTRACT FROM AUTHOR]

Six different therapies that have been used to treat low self-esteem are reviewed. Although their clinical approaches are very diverse, all of them, nevertheless, end up improving the patient's self-esteem. To try to answer this question, we approach this review in two successive phases. First, the clinical profile of each therapy will be extracted and analyzed - e.g., its etiology, assumptions, therapeutic objectives or treatment techniques; and, secondly, its specific mechanisms of action (AM) -its therapeutic nucleus-will be compared with respect to the achievement of the patient's personal objectives - positioning those on a system of components of personal competence and efficacy. It is concluded that all the therapies would be effective because, although each one of them acts only on one or two components, its effect would then radiate through the system from there to self-esteem. Se revisan seis terapias diferentes que se vienen utilizando para tratar la baja autoestima. Aunque sus enfoques clínicos son muy diversos, todas ellas, sin embargo, acaban por mejorar la autoestima del paciente. Para intentar responder a esta cuestión, abordamos esta revisión en dos fases sucesivas. Primero, se extraerá y analizará el perfil clínico de cada terapia -e.g., su etiología, supuestos, objetivos terapéuticos o técnicas de tratamiento; y, en segundo lugar, se compararán sus específicos mecanismos de acción (MA) -su núcleo terapéutico-respecto del logro de objetivos personales del paciente -posicionando aquellos sobre un sistema componentes de competencia y eficacia personales. Se concluye que todas las terapias resultarían eficaces porque, aunque cada una de ellas actúe únicamente sobre uno o dos componentes, su efecto se irradiaría luego por el sistema desde ahí hasta la autoestima. [ABSTRACT FROM AUTHOR]

Policosanol is a promising compound that can be used in various industries. In the pharmaceutical industry, policosanol and, specifically, triacontanol, octacosanol, and hexacosanol have presented biological activity against several diseases, especially those related to inflammation and hypercholesterolaemia. On the other hand, triacontanol is used as a growth promoter in a wide variety of plants and crops of economic importance, even in microalgal culture, in either its pure form or in policosanol extracts. In this review, the most relevant references to the bioactivities of policosanol in plants and animal cells are collected to compare the different mechanisms of action. Analyzing this in detail allows us to ask new research questions. The PubMed and Redalyc database were used for article search under the following keys terms: policosanol, inflammatory mechanisms, triacontanol, cellular absorption, photosynthesis and photoinhibition. Policosanol interferes with the progression of the NF-κB and MAPK signaling pathway involved in the inflammation process. The cholesterol-lowering effect of policosanol is due to the inhibition of cholesterol synthesis in the liver, through the indirect inactivation of HMGCoA reductase. Triacontanol improves the growth and the biochemical and physiological parameters of plants and the response to stress conditions that is related mainly to photosynthetic activity. Interestingly, octacosanol demonstrates an inhibitory activity on the effect of triacontanol in plants, a response not reported in human cells, as well as other differential aspects of the mechanisms of action in the cells of plants and animals that are interesting to analyze. [ABSTRACT FROM AUTHOR]

Background: The general aim of the study was to examine the relative effectiveness and mediators of change in standardized mindfulness and compassion interventions.Methods: A sample of 431 participants enrolled in a Mindfulness-Based Stress Reduction program (MBSR = 277) and a Compassion Cultivation Training (CCT = 154). The assessment before and after the program included a set of outcomes and mediators measures. A three-step data analysis plan was followed: ANCOVAs, Reliable Change Index, and mediations (simple and multiple).Results: Both interventions yielded increased mindfulness, decentering, body awareness, and self-compassion. Yet, present-moment awareness improvements (i.e., decentering, and body awareness) were significantly larger in the MBSR than in CCT, whereas socio-emotional changes (i.e., common humanity and empathic concern) were larger in the CCT than in MBSR. The magnitude of effect sizes ranged from medium to large. Furthermore, both mindfulness and compassion interventions yielded similar changes in psychological distress (i.e., stress, anxiety, and depression), maladaptive cognitive processes (i.e., rumination and thought suppression), and well-being. The mediation models showed that although the MBSR program seemingly relies on changes in present-moment awareness mechanisms (i.e., decentering and body awareness) to reduce psychological distress and to improve well-being, the CCT program seemingly achieves the same positive outcomes through changes in socio-emotional mechanisms (i.e., common-humanity and empathy concern).Limitations: Due to our naturalistic design in real-world community setting, it was infeasible to randomly assign participants to conditions.Conclusions: Our results suggest that mindfulness and compassion programs operate through different pathways to reduce psychological distress and to promote well-being. [ABSTRACT FROM AUTHOR]

Abstract Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes their functions. In this paper, the applications of differential proteomics in exploring the action mechanisms of TCMs on various diseases including cancers, cardiovascular diseases, diabetes, liver diseases, kidney disorders and obesity, etc. were reviewed. Furthermore, differential proteomics in studying of TCMs identification, toxicity, processing and compatibility mechanisms were also included. This review will provide information for the further applications of differential proteomics in TCMs studies.

Yessotoxin (YTX) is a polyether. There are more than 90 known derivatives of yessotoxin. YTX was excluded from diarrhea toxins group as it, unlike okadaic acid, doesn't cause diarrhea. YTX chemical structure is similar to that of brevetoxins and ciguatoxins that influence functioning of calcium-sodium pump and trans-membrane ion channels. So, YTX can exert influence on functioning of all the organs and systems in a body. YTX is known to promote apoptosis in the cerebral tissues. Average lethal dose LD50 for YTX and its analogues varied from 100 µg/kg to 500-750 µg/kg; the figures were obtained in various experiments performed on mice. Safe YTX level for acute impact (acute reference dose) amounts to 25 μM/kg of body weight. Nowadays toxicity parameters for YTX and some of its analogues are determined; its basic action mechanisms and a role it plays in promoting apoptosis are well-known. In spite of more and more data on biological effects produced by YTX on a warm-blooded organism, experts are still unable to describe its action mechanisms precisely. Our research goal was to examine YTX toxicity in experiments in vivo in doses that were lower than the detected acute reference dose. The experiment was performed on 72 male Wistar rats with initial body weight being equal to 100±10 г. Animals were given dry balanced feedstuff produced by "Laboratortakorm" LLC (Russia) and had free access to it. We used YTX preparation produced by "National Research Council Canada" (Canada) in our experiment; the preparation was a methanol solution (YTX content was equal to 4.3 µmol). We determined mass of internal organs, biochemical and hematological blood parameters, apoptosis of brain cells, malonic dialdehyde level in the brain and reduced glutathione in the liver. We showed that YTX doses (2μM/kg, 8μM/kg and 12μM/kg) lower than ARfD=2μM/kg can exert toxic impacts on a warm-blooded organism. The obtain data prove it is necessary to additionally assess risks of an increase in maximum permissible YTX contents in shellfish from 1 mg/kg to 3.75 mg/kg.

This article aims to draw an overview on the actual knowledge on bacteriostatic and bactericidal natural clays. Particular emphasis is given to the role of clay itself, the action of reduced metals located either in the structure of clay minerals or external to them as constituents of associate minerals, and the definition of the mechanisms of action based on the achievements found in all available studies being carried out so far. The term bactericidal is herein used when a clay or a clay mineral kill the bacteria, whereas the term bacteriostatic is used when those minerals stop bacteria growth and replication. The second part of this article deals with experimental studies on bactericidal natural clay, experience and perspective for the preparation of bactericidal natural clays, interesting on the authors perspective and experience for the preparation of pathogens safe both therapeutic and cosmetic natural mud/natural peloid, and better yet of both therapeutic 87oooand cosmetic peloid itself and designed and engineered peloid. The authors also show how to convert non-antimicrobial clay into antimicrobial one, opening the way in the field of pelotherapy to the preparation of sanitary safe peloids addressed, for instance, to the treatment of rheumatic disabilities, as well as to the preparation of antimicrobial peloids and, in particular, of dermatological ointments, all able to fight infectious skin disorders. [ABSTRACT FROM AUTHOR]

Background: Dermatophytes belonging to the Trichophyton genus are important human pathogens, but they have developed resistance to griseofulvin, the most common antifungal drug used to treat dermatophytosis. Objective: This study was aimed to evaluate the antidermatophytic activity of synthetic peptides, as well as mechanisms of action and synergistic effect with griseofulvin. Methods: Scanning electron microscopy (SEM), atomic force microscopy (AFM) and fluorescence microscopy (FM) were employed to understand the activity and the mechanism of action of peptides. Results: Here we report that synthetic peptides at 50 μg/mL, a concentration 20‐fold lower than griseofulvin, reduced the microconidia viability of T. mentagrophytes and T. rubrum by 100%, whereas griseofulvin decreased their viability by only 50% and 0%, respectively. The action mechanism of peptides involved cell wall damage, membrane pore formation and loss of cytoplasmic content. Peptides also induced overproduction of reactive oxygen species (ROS) and enhanced the activity of griseofulvin 10‐fold against both fungi, suggesting synergistic effects, and eliminated the toxicity of this drug to human erythrocytes. Docking analysis revealed ionic and hydrophobic interactions between peptides and griseofulvin, which may explain the decline of griseofulvin toxicity when mixed with peptides. Conclusion: Therefore, our results strongly suggest six peptides with high potential to be employed alone as new drugs or as adjuvants to enhance the activity and decrease the toxicity of griseofulvin. [ABSTRACT FROM AUTHOR]