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Introduction: The concept of menopause is a complete cessation of ovarian function. Most common symptom of menopause include muscle and joint ache, poor memory, lower back pain and trouble sleeping. The vasomotor and emotional domains reported less often compared with the physical and psychological domains. Such adverse changes in physical and mental health may have a negative impact on Quality of Life (QOL). Pilates is a mind body exercise focusing on muscle strength, core stability, endurance, muscle control, posture, and respiration which seems to improve both the physical and psychological components in women during menopause. The given study helps to provide the effect of 6 weeks Pilates training protocol on menopausal women’s presenting complaints as well as on her QOL. Complaints and clinical finding: Patient’s main concern were low back ache without any cause night sweats, fatigue, disturbed sleep wake cycle which lead to difficulties in performing activities of daily living which hampered the QOL of the patient. Physical findings revealed decrement in lower back and lower limb muscle strength along with some tightness. Scales helped to reveal that patient is having fatigue and tiredness and mat-exercise treatment protocol were formed. Therapeutic Intervention: 6 weeks Pilates training. Conclusion: As there are minimal to no evidence present in reference to this study, it helps us to provide new and proper treatment protocol and it is helpful to know the effect of the same. It showed significant improvement in the muscular strength as well as reduction in stress level and helped in enhancing the QOL of the patient.