1. Coronary Spasm after an Injection of Vincristine.
- Author
-
Gros, Rosine, Hugon, Vincent, Thouret, Jean-Marc, and Peigne, Vincent
- Subjects
ESOPHAGEAL achalasia ,VINCRISTINE ,CARDIOTOXICITY ,CHEMOTHERAPY complications ,CARDIOLOGISTS ,ONCOLOGISTS ,THERAPEUTICS - Abstract
Cardiotoxicity, including heart failure, thromboembolic events, and myocardial ischemia, is a concern for cardiologists and oncologists. The most frequently involved drugs are anthracyclines. We report an episode of coronary spasm due to vincristine, a vinca alkaloid, in a 49-year-old man treated for a diffuse undifferentiated carcinoma. The patient suffered recurrent episodes of typical chest pain with ST-elevation in the inferior area. Coronary spasm was confirmed by an angiogram, which showed normal coronary arteries. No recurrence occurred with the medical management. Coronary spasm induced by vincristine is a newly described facet of chemotherapy-related cardiotoxicity. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF