1. Ferroptosis in acute kidney injury following crush syndrome: A novel target for treatment.
- Author
-
Qiao, Ou, Wang, Xinyue, Wang, Yuru, Li, Ning, and Gong, Yanhua
- Subjects
- *
CRUSH syndrome , *ACUTE kidney failure , *KIDNEY tubules , *IRON overload , *CELL death , *PROXIMAL kidney tubules , *KIDNEYS , *MYOGLOBIN - Abstract
[Display omitted] • Inhibiting ferroptosis could alleviate acute kidney injury following crush syndrome. • Iron overload produced by myoglobin degradation is a risk factor for ferroptosis. • HMGB1 and souble-stranded DNA trigger ferroptosis via multiple signaling pathways. • Crosstalk between inflammation and ferroptosis. • Inhibition of ferroptosis by alleviating inflammation and anti-lipid peroxidation. Crush syndrome (CS) is a kind of traumatic and ischemic injury that seriously threatens life after prolonged compression. It is characterized by systemic inflammatory reaction, myoglobinuria, hyperkalemia and acute kidney injury (AKI). Especially AKI, it is the leading cause of death from CS. There are various cell death forms in AKI, among which ferroptosis is a typical form of cell death. However, the role of ferroptosis has not been fully revealed in CS-AKI. This review aimed to summarize the evidence of ferroptosis in CS-AKI and its related molecular mechanism, discuss the therapeutic significance of ferroptosis in CS-AKI, and open up new ideas for the treatment of CS-AKI. One of the main pathological manifestations of CS-AKI is renal tubular epithelial cell dysfunction and cell death, which has been attributed to massive deposition of myoglobin. Large amounts of myoglobin released from damaged muscle deposited in the renal tubules, impeding the normal renal tubules function and directly damaging the tubules with oxidative stress and elevated iron levels. Lipid peroxidation damage and iron overload are the distinguishing features of ferroptosis. Moreover, high levels of pro-inflammatory cytokines and damage-associated molecule pattern molecules (HMGB1, double-strand DNA, and macrophage extracellular trap) in renal tissue have been shown to promote ferroptosis. However, how ferroptosis occurs in CS-AKI and whether it can be a therapeutic target remains unclear. In our current work, we systematically reviewed the occurrence and underlying mechanism of ferroptosis in CS-AKI. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF