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Your search keyword '"Lopez-Tofiño A"' showing total 4 results
Start Over Author "Lopez-Tofiño A" Topic acute kidney injury
4 results on '"Lopez-Tofiño A"'

1. Risk factors for acute kidney injury in critically ill patients with complicated intra-abdominal infection.

Author

Suarez-de-la-Rica A, Anillo V, Montero A, Hernandez-Gancedo C, Lopez-Tofiño A, Gilsanz F, and Maseda E

Subjects
Acute Kidney Injury blood, Acute Kidney Injury epidemiology, Acute Kidney Injury etiology, Acute Kidney Injury therapy, Aged, Creatinine blood, Critical Care, Female, Humans, Intensive Care Units, Male, Organ Dysfunction Scores, Patient Admission, Renal Replacement Therapy, Risk Factors, Spain epidemiology, Acute Kidney Injury mortality, Critical Illness, Intraabdominal Infections complications, Surgical Wound Infection complications
Abstract

Purpose: The aim was to determine the factors related to acute kidney injury (AKI) in surgical septic patients with complicated intra-abdominal infection (CIAI) and mortality associated to AKI., Methods: An observational study was performed in patients with CIAI requiring surgery and ICU admission (June 2011-June 2013). Factors at admission associated with developing of AKI and renal replacement therapy (RRT) and association between mortality and AKI and RRT were studied., Results: A total of 114 patients were included. Developing of AKI was independently associated with the sequential organ failure assessment (SOFA) score (odds ratio [OR], 1.570; 95% confidence interval [CI], 1.286-2.016) and creatinine at admission (OR for 0.1 units, 1.560; 95% CI, 1.296-1.990). Renal replacement therapy was independently associated with arterial hypertension (OR, 4.896; 95% CI, 1.501-15.971) and SOFA (OR, 1.713; 95% CI, 1.377-2.132). In another model with more predictive capacity, the number of previous medications that may alter renal function (OR, 3.732; 95% CI, 1.923-8.383) and SOFA (OR, 1.860; 95% CI, 1.469-2.541) were related to RRT. Both AKI and RRT were related to intensive care unit (P=.014 and P<.001, respectively) and 28-day mortality (P=.045 and P<.001, respectively)., Conclusions: Acute kidney injury in patients with CIAI is clearly associated with SOFA and creatinine at admission. Severe AKI with RRT need is highly associated with both previous arterial hypertension and the number of previous medications potentially affecting renal function., (Copyright © 2016 Elsevier Inc. All rights reserved.)

Published
2017
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3. Severe cefepime-induced status epilepticus treated with haemofiltration

Author

Fernando Gilsanz, Araceli Lopez-Tofiño, Emilio Maseda, C. Hernández-Gancedo, and Alejandro Suarez-de-la-Rica

Subjects
medicine.medical_treatment, Cefepime, 030232 urology & nephrology, Status epilepticus, Critical Care and Intensive Care Medicine, Meropenem, 03 medical and health sciences, Status Epilepticus, 0302 clinical medicine, Hemofiltration, Humans, Medicine, Renal replacement therapy, Aged, Coma, business.industry, Acute kidney injury, Electroencephalography, 030208 emergency & critical care medicine, Acute Kidney Injury, medicine.disease, Anesthesiology and Pain Medicine, Sodium thiopental, Anesthesia, Female, medicine.symptom, business, medicine.drug
Abstract

Neurotoxicity caused by cefepime may occur predominantly in patients with impaired renal function. A case of a cefepime-induced non-convulsive status epilepticus (NCSE) is presented. A 65-year-old woman suffered a severe NCSE due to cefepime in the presence of acute renal failure, requiring coma induction with sodium thiopental. A serious interaction between valproic acid (VPA) and meropenem was also produced after changing cefepime to meropenem. Continuous veno-venous haemofiltration was employed to improve cefepime clearance, and the patient progressively regained her previous mental condition. In conclusion, the cefepime dose must be adjusted according to renal function in order to avoid toxicity in patients with renal failure. Electroencephalogram should be considered in cases of acute confusional state in patients receiving cefepime, to achieve early detection of NCSE. Continuous renal replacement therapy may be successfully employed in severe cases in order to accelerate cefepime removal. Likewise, meropenem should not be used concomitantly with VPA.

Published
2016
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4. Risk factors for acute kidney injury in patients with complicated intra-abdominal infection

Author

C. Hernández-Gancedo, Víctor Anillo, Maria-Jose Villagran, Araceli Lopez-Tofiño, Fernando Gilsanz, A Suárez de la Rica, and Emilio Maseda

Subjects
medicine.medical_specialty, Pediatrics, urogenital system, business.industry, Acute kidney injury, bacterial infections and mycoses, urologic and male genital diseases, Critical Care and Intensive Care Medicine, medicine.disease, female genital diseases and pregnancy complications, Poster Presentation, Emergency medicine, medicine, In patient, business, Intra-Abdominal Infection
Abstract

AKI has been poorly studied in surgical septic patients. The aim of our study was to determine the factors related to AKI in surgical septic patients with complicated intra-abdominal infection (CIAI) and mortality associated with AKI in this setting.

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