Chang, Hui-Qin, Jia, Lei, Xu, Jun, Xu, Zhou-Qing, Chen, Ru-Hua, Wu, Wei-Na, Bie, Hong-Yan, Zhu, Tao-Feng, Ma, Tie-liang, and Wang, Yuan
Three novel complexes, [Cu 4 (L) 4 Cl 4 ]·H 2 O ( 1 ), Zn(L) 2 ( 2 ) and Cd(L) 2 ( 3 ), based on HL (where HL = 2-acetylpyridine isonicotinohydrazone) were synthesized and characterized by X-ray diffraction analyses. In the tetranuclear complex 1 , each copper(II) ion with a distorted square-planar coordination geometry is five-coordinated by one chloride anion, one ON 2 donor set and one 4-pyridine nitrogen atom from another adjacent actylhydrazone ligand. However, the central ions in complexes 2 and 3 possess distorted octahedral coordination geometry, surrounded by two ON 2 donor sets. In addition, all the complexes have excellent antitumor activity towards human lung cancer (A549) and human gastric cancer (SGC7901 and BGC823) cell lines. Furthermore, cell apoptosis induced by complex 1 was detected through TUNEL and Annexin V/PI staining with flow cytometric analysis and western blotting analysis. [ABSTRACT FROM AUTHOR]