1. Small therapeutic molecules for the treatment of inflammatory bowel disease
- Author
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S. J. H. Van Deventer, Extramural researchers, and Faculteit der Geneeskunde
- Subjects
Paper ,medicine.medical_specialty ,MAP Kinase Signaling System ,Phosphodiesterase Inhibitors ,medicine.medical_treatment ,Receptors, Cytoplasmic and Nuclear ,ADAM17 Protein ,Nitric Oxide ,Inflammatory bowel disease ,Gastroenterology ,Crohn Disease ,Internal medicine ,Humans ,Medicine ,Protein Precursors ,Chemotherapy ,Tumor Necrosis Factor-alpha ,business.industry ,Crohn disease ,Metalloendopeptidases ,Inflammatory Bowel Diseases ,medicine.disease ,Ulcerative colitis ,Thalidomide ,ADAM Proteins ,Immunology ,Eicosanoids ,business ,Signal Transduction ,Transcription Factors - Abstract
New therapies for inflammatory bowel disease are needed, because standard therapies fail to induce remission in about 30% of patients, and because of the relative inefficacy of current maintenance therapies. This review summarises the current status of the development of small therapeutic molecules for inflammatory bowel disease.
- Published
- 2002