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Your search keyword '"Bian, Qing-Hua"' showing total 2 results
Start Over Author "Bian, Qing-Hua" Topic addition reactions
2 results on '"Bian, Qing-Hua"'

1. Catalytic asymmetric synthesis of (S,4E,15Z)-docosa-4,15-dien-1-yn-3-ol, an antitumor marine natural product.

Author

Liu, Fei-Peng, Zhong, Jiang-Chun, Zheng, Bing, Li, Shuo-Ning, Gao, Gui, Wang, Zhong-Yu, Li, Min-Yan, Hou, Shi-Cong, Wang, Min, and Bian, Qing-Hua

Subjects
*ACETYLENE, *LIGANDS (Chemistry), *CATALYTIC activity, *ANTINEOPLASTIC agents, *ADDITION reactions, *NATURAL products
Abstract

An efficient enantioselective total synthesis of an antitumor marine natural product ( S ,4 E ,15 Z )-docosa-4,15-dien-1-yn-3-ol 1 with 96% ee and 15% overall yield has been achieved; this is the first preparation of 1 via asymmetric catalytic strategy. The key steps involve the asymmetric addition of trimethylsilylacetylene to a diolefinc aldehyde using a ( R , R )-ProPhenol ligand and a zipper reaction of an alkyne. [ABSTRACT FROM AUTHOR]

Published
2015
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