1. Microsecretory adenocarcinoma of the external ear canal.
- Author
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Dibbern ME, Gru AA, and Stelow EB
- Subjects
- Female, Humans, Aged, 80 and over, In Situ Hybridization, Fluorescence, Ear Canal metabolism, Ear Canal pathology, Immunohistochemistry, S100 Proteins genetics, Biomarkers, Tumor genetics, Adenocarcinoma pathology, Salivary Gland Neoplasms genetics
- Abstract
Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor characterized by unique histomorphologic and immunohistochemical features as well as recurrent MEF2C::SS18 gene fusion. Since 2019, 24 cases have been reported in the literature, primarily arising in the oral cavity, with a single reported case arising in the parotid gland. Here, we present a case of MSA that arose in the external ear canal in an 89-year-old woman and was discovered during management of vertigo symptoms. Excisional biopsy of the lesion showed multiple fragments of squamous epithelium with hyperplastic changes and a distinct subepithelial infiltrating neoplasm composed of bland cells forming tubules and cords. Neoplastic cells expressed keratin, S100 protein, p63, and TLE1 and did not express p40, mammaglobin, pan-TRK, synaptophysin, or chromogranin by immunohistochemistry. SS18 gene rearrangement was shown with break-apart fluorescent in situ hybridization. Overall, the histomorphologic, immunohistochemical, and cytogenetic findings confirm a diagnosis of MSA arising in a unique extraoral location., (© 2022 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.)
- Published
- 2023
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