1. Assessing clinical pathological characteristics and gene expression patterns associated with hepatoid adenocarcinoma of the stomach.
- Author
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Ge DF, Wang YK, Li YY, Liao XH, Zhu CY, Jiang B, and Wang SN
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Aged, 80 and over, Adult, Biomarkers, Tumor genetics, Diagnosis, Differential, Receptor, ErbB-2 metabolism, Receptor, ErbB-2 genetics, Stomach Neoplasms genetics, Stomach Neoplasms pathology, Stomach Neoplasms metabolism, Adenocarcinoma genetics, Adenocarcinoma pathology, alpha-Fetoproteins metabolism, alpha-Fetoproteins analysis
- Abstract
Objective: The objective of this study is to assess the clinical pathological attributes of Hepatoid Adenocarcinoma of the Stomach (HAS) and to delineate the differential diagnostic considerations about it., Method: The investigation involved analyzing 31 HAS cases using histomorphological assessment, immunohistochemical profiling, and relevant gene detection methodologies., Results: Among the 31 HAS cases, 9 (29.0%) were of trabecular hepatoid adenocarcinoma of the stomach, 7 (22.6%) were of glandular hepatoid adenocarcinoma of the stomach, 4 (12.9%) were of nesting hepatoid adenocarcinoma of the stomach, 3 (9.7%) were of clear cell hepatoid adenocarcinoma of the stomach, and 8 (25.8%) were of diverse hepatoid adenocarcinoma of the stomach. Of these 31 cases, 24 were male, accounting for 77.4% of the cases. Serum alpha-fetoprotein (AFP) levels were notably elevated, with radioimmunoassay results reaching 1240 ng/ml; 28 out of 31 cases had AFP levels below 25 µg/l, accounting for 90.3%. Related genes: HER2 protein indicated positive expression on the cell membrane in 35.5% (11/31) of the cases; HER2 gene amplification detected by the FISH technique was 12.9% (4/31). Tumoral stromal lymphocytes exhibited a PD-1 positive expression rate of 58.1% (18/31). In gastric cancer tissues, the PD-L1 positive rate was 45.1% (14/31)., Conclusion: HAS represents a distinctive subtype of gastric cancer with a propensity for mimicking other forms of tumors, underscoring the significance of discerning its unique histopathological attributes for accurate differential diagnosis and tailored therapeutic interventions., (© 2024. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)
- Published
- 2024
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