1. Elevation of sialyl stage-specific mouse embryonic antigen levels in pleural effusion in patients with adenocarcinoma of the lung
- Author
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Yasuhiro Ohtsu, Kazuhiro Miyazaki, Mitsuo Ohta, Nobuyuki Hara, Haruo Iguchi, and Fumitaka Sonoda
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Lung Neoplasms ,Pleural effusion ,Radioimmunoassay ,Lewis X Antigen ,Adenocarcinoma ,Carcinoembryonic antigen ,Antigens, Neoplasm ,Adenocarcinoma of the lung ,medicine ,Humans ,Lung cancer ,Aged ,Aged, 80 and over ,Lung ,biology ,business.industry ,Respiratory disease ,Middle Aged ,medicine.disease ,Carcinoembryonic Antigen ,Pleural Effusion ,medicine.anatomical_structure ,Oncology ,embryonic structures ,biology.protein ,Female ,Glycolipids ,business ,Oncofetal antigen - Abstract
Sialyl stage-specific mouse embryonic antigen (SSEA-1) levels were measured in pleural effusions obtained from patients with lung cancer and benign pulmonary disease, using a solid-phase immunoradiometric sandwich assay. The mean (+/- SEM) levels (unit/ml) of pleural fluid sialyl SSEA-1 were 3620 +/- 1419 in adenocarcinoma (n = 25), 123 +/- 30 in nonadenocarcinoma (n = 13) and 95 +/- 19 in benign pulmonary disease (n = 13), respectively. The positive rate was 64% in adenocarcinoma, 7.7% in nonadenocarcinoma, and 0% in benign pulmonary disease, respectively, when a cutoff level was defined as the mean + 3 SD value (300 unit/ml) based on pleural fluid sialyl SSEA-1 levels in benign pulmonary disease. There was a significant positive correlation between pleural fluid levels of sialyl SSEA-1 and those of carcinoembryonic antigen in adenocarcinoma patients (r = 0.8246, P less than 0.01). Pleural fluid sialyl SSEA-1 levels correlated with cytologic findings in adenocarcinoma patients. These observations suggest that sialyl SSEA-1 in pleural effusion is a useful marker to discriminate malignant from nonmalignant and adenocarcinoma from nonadenocarcinoma of the lung.
- Published
- 1989
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