1. A meta-analysis of the association between glutathione S-transferase P1 gene polymorphism and the risk of adenocarcinomas of lung cancer.
- Author
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Zhong, Hong, Feng, Yi, Zheng, Gui-Xiong, Liang, Yan, Zhang, Jun-Yuan, Zheng, Bao-Shi, and Feng, Xu
- Subjects
LUNG cancer ,ADENOCARCINOMA ,GLUTATHIONE ,HISTOLOGY ,SQUAMOUS cell carcinoma - Abstract
BACKGROUND: Results of the published reports on the relationship between glutathione S-transferase P1 (GSTP1) gene polymorphism and the adenocarcinomas of lung cancer are still debated. OBJECTIVE: This meta-analysis was performed to evaluate the association between GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. METHODS: The association investigations were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method.RESULTS: 16 reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and the risk of adenocarcinomas of lung cancer. The G allele and GG genotype were not associated with the susceptibility of risk of adenocarcinomas. Furthermore, in the sensitivity analysis, the results were similar with those from the non-sensitivity analysis. CONCLUSIONS: GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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