1. Association of RET codon 691 polymorphism in radiation-induced human thyroid tumours with C-cell hyperplasia in peritumoural tissue.
- Author
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Bounacer A, Du Villard JA, Wicker R, Caillou B, Schlumberger M, Sarasin A, and Suárez HG
- Subjects
- Adenoma etiology, Adenoma pathology, Adolescent, Adult, Aged, Carcinoma, Papillary etiology, Carcinoma, Papillary pathology, Cell Transformation, Neoplastic, Child, Child, Preschool, Codon, Dose-Response Relationship, Radiation, Epithelial Cells pathology, Epithelial Cells radiation effects, Female, Humans, Hyperplasia, Lymphocytes metabolism, Male, Middle Aged, Neoplasms, Radiation-Induced pathology, Proto-Oncogene Mas, Proto-Oncogene Proteins c-ret, Thyroid Neoplasms etiology, Thyroid Neoplasms pathology, Adenoma genetics, Carcinoma, Papillary genetics, Drosophila Proteins, Neoplasms, Radiation-Induced genetics, Polymorphism, Single Nucleotide genetics, Proto-Oncogene Proteins genetics, Receptor Protein-Tyrosine Kinases genetics, Thyroid Neoplasms genetics
- Abstract
The RET proto-oncogene encodes a protein structurally related to transmembrane receptors with an intracellular tyrosine kinase domain. In human thyroid gland, the RET proto-oncogene is normally expressed in parafollicular C-cells. Thyroid C-cell hyperplasia is associated with inherited medullary thyroid carcinomas and is considered as a pre-neoplastic stage of C-cells disease. It has also been observed in thyroid tissues adjacent to follicular and papillary carcinomas. In order to study the relationship between a misfunctioning of the RET proto-oncogene and the presence of C-cell hyperplasia, we compared a series of thyroid glands presenting sporadic or radiation-associated tumours, as well as samples of unrelated normal thyroid tissues, for alteration in exons 10 and 11 of the gene and for the presence or absence of C-cell hyperplasia. Here we report a significantly higher frequency of C-cell hyperplasia present in peritumoural thyroid tissues of radiation-induced epithelial thyroid tumours, than in peritumoural of sporadic thyroid tumours or in control normal thyroid tissues (P=0.001). A G691S RET polymorphism was present with a higher frequency in radiation-induced epithelial thyroid tumours (55%) than in sporadic tumours (20%) and in control normal thyroid tissues (15%). Interestingly, this polymorphism was associated in the majority (88%) of radiation-induced tumours with a C-cell hyperplasia in the peritumoural tissues. Several explanations for this association are discussed., (Copyright 2002 Cancer Research UK)
- Published
- 2002
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