Search

Your search keyword '"Griseolic acid"' showing total 5 results
Start Over Descriptor "Griseolic acid" Topic adenosine
5 results on '"Griseolic acid"'

1. Studies on griseolic acid derivatives. V. Synthesis and phosphodiesterase inhibitory activity of substituted derivatives of the hydroxy group at the 2'- or 7'-position in griseolic acid

Author

Yasuteru Iijima, Misako Kimura, Yoshinobu Murofushi, Masakatsu Kaneko, and Mitsuo Yamazaki

Subjects
Adenosine, Chemical Phenomena, Phosphodiesterase Inhibitors, Stereochemistry, Hydroxy group, Phosphodiesterase, General Chemistry, General Medicine, Griseolic acid, In Vitro Techniques, Inhibitory postsynaptic potential, Rats, Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Animals
Published
1987
Full Text
View/download PDF

2. Studies on griseolic aicd derivatives. VI. Synthesis and phosphodiesterase-inhibitory activity of 6- and N1-substituted derivatives of griseolic acid

Author

Yasuteru Iijima, Masakatsu Kaneko, Mitsuo Yamazaki, Yoshinobu Murofushi, and Misako Kimura

Subjects
Adenosine, Chemical Phenomena, Phosphodiesterase Inhibitors, Chemistry, Stereochemistry, Phosphodiesterase, General Chemistry, General Medicine, Griseolic acid, Inhibitory postsynaptic potential, 3',5'-Cyclic-AMP Phosphodiesterases, Drug Discovery, Organic chemistry
Published
1988
Full Text
View/download PDF

3. Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. I. Taxonomy, isolation and characterization

Author

Takao Okazaki, Atsushi Naito, Mitsuo Yamazaki, Fumio Nakagawa, and Yasuteru Iijima

Subjects
Adenosine, Chemical Phenomena, Stereochemistry, Griseolic acid, In Vitro Techniques, chemistry.chemical_compound, Streptomyces griseoaurantiacus, Drug Discovery, Cyclic AMP, medicine, Animals, Moiety, Aorta, Pharmacology, chemistry.chemical_classification, Phosphodiesterase, Phosphate, Streptomyces, Rats, Chemistry, Enzyme, Adenosine 3 5 monophosphate, chemistry, Biochemistry, 3',5'-Cyclic-AMP Phosphodiesterases, medicine.drug
Abstract

Griseolic acid, a potent inhibitor of cyclic adenosine 3',5'-monophosphate (cyclic AMP) phosphodiesterase (EC 3.1.4.17) was isolated from the cultured broth of Streptomyces griseoaurantiacus SANK 63479. Griseolic acid has an adenine moiety and two carboxyl groups and possesses the molecular formula C14H13N5O8. Griseolic acid inhibited cyclic AMP phosphodiesterase competitively with regard to cyclic AMP, the substrate and the resulting Ki value was 0.26 microM. Griseolic acid showed the most potent inhibitory effect on rat aorta cyclic AMP phosphodiesterase among the enzymes of several rat organs tested. The plasma level of cyclic AMP was increased when griseolic acid was subcutaneously injected rats.

Published
1985
Full Text
View/download PDF

4. Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group

Author

Fumio Nakagawa, Mitsuo Yamazaki, Tomiichiro Oda, Yasuteru Iijima, Shuji Handa, and Atsushi Naito

Subjects
Blood Glucose, Male, medicine.medical_specialty, Adenosine, Griseolic acid, Lipolysis, Guinea Pigs, Biophysics, Mice, Inbred Strains, In Vitro Techniques, Biochemistry, Cyclase, Glucagon, Guinea pig, Mice, Theophylline, Structural Biology, Internal medicine, cAMP, Cricetinae, Genetics, medicine, Cyclic AMP, Animals, Phosphodiesterase inhibitor, Protein kinase A, Molecular Biology, Cyclic GMP, Cerebral Cortex, Chemistry, Phosphodiesterase, Brain, Rats, Inbred Strains, Cell Biology, Liver Glycogen, Rats, cGMP, Kinetics, Endocrinology, Adipose Tissue, Liver, 3',5'-Cyclic-AMP Phosphodiesterases, medicine.drug
Abstract

Griseolic acid inhibited cAMP phosphodiesterase (PDE) at low concentrations, the I50 being of the order of 0.01–0.1 μM. Administration of griseolic acid to rats increased the cAMP level in liver and plasma several-fold. It increased glycogen degradation in mouse liver and stimulated lipolysis in isolated rat fat cells. Griseolic acid did not block the adenosine-elicited accumulation of cAMP in guinea pig brain slices. It had no effect on cAMP-dependent protein kinase from rat liver nor on the adenyl cyclase from rat brain.

Published
1985

5. Griseolic acid, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. II. The structure of griseolic acid

Author

Chihiro Tamura, Shuji Takahashi, Atsushi Naito, Kayoko Kawazoe, Sadao Sato, Yoji Furukawa, and Fumio Nakagawa

Subjects
Adenosine, Magnetic Resonance Spectroscopy, Stereochemistry, Molecular Conformation, Griseolic acid, Streptomyces griseoaurantiacus, Drug Discovery, medicine, Chemical decomposition, Pharmacology, Chromatography, Crystallography, biology, Cyclic nucleotide phosphodiesterase, Chemistry, Hydrolysis, Methanol, Phosphodiesterase, Acetylation, Adenine nucleoside, Biochemistry, Diazomethane, Enzyme inhibitor, 3',5'-Cyclic-AMP Phosphodiesterases, biology.protein, medicine.drug
Abstract

Griseolic acid, a potent inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase, was isolated from the fermentation broth of Streptomyces griseoaurantiacus SANK 63479. Treatment of griseolic acid with HCl-MeOH gave adenine and pseudo-sugar. The structure of griseolic acid, adenine nucleoside type structure, was elucidated by chemical degradation and X-ray analysis, and was shown to be structure 1.

Published
1985

Catalog

Books, media, physical & digital resources
See catalog results