1. Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets †.
- Author
-
Taliani, Sabrina, Da Settimo, Federico, Martini, Claudia, Laneri, Sonia, Novellino, Ettore, Greco, Giovanni, Catto, Marco, and Altomare, Cosimo Damiano
- Subjects
- *
TRANSLOCATOR proteins , *CHLORIDE channels , *ADENOSINES , *INDOLE , *INDOLE derivatives , *MOLECULES - Abstract
Several indole derivatives have been disclosed by our research groups that have been collaborating for nearly 25 years. The results of our investigations led to a variety of molecules binding selectively to different pharmacological targets, specifically the type A γ-aminobutyric acid (GABAA) chloride channel, the translocator protein (TSPO), the murine double minute 2 (MDM2) protein, the A2B adenosine receptor (A2B AR) and the Kelch-like ECH-associated protein 1 (Keap1). Herein, we describe how these works were conceived and carried out thanks to the versatility of indole nucleus to be exploited in the design and synthesis of drug-like molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF