1. 7-MEGA™ inhibits adipogenesis in 3T3-L1 adipocytes and suppresses obesity in high-fat-diet-induced obese C57BL/6 mice.
- Author
-
Won YS, Bak SG, Chandimali N, Park EH, Lim HJ, Kwon HS, Park SI, and Lee SJ
- Subjects
- Animals, Mice, Male, PPAR gamma metabolism, PPAR gamma genetics, Sterol Regulatory Element Binding Protein 1 metabolism, Sterol Regulatory Element Binding Protein 1 genetics, Stearoyl-CoA Desaturase metabolism, Stearoyl-CoA Desaturase genetics, Mice, Obese, Fatty Acid-Binding Proteins metabolism, Fatty Acid-Binding Proteins genetics, Adipokines metabolism, Anti-Obesity Agents pharmacology, Uncoupling Protein 1 metabolism, Uncoupling Protein 1 genetics, Adipose Tissue, White metabolism, Adipose Tissue, White drug effects, CCAAT-Enhancer-Binding Proteins, Diet, High-Fat adverse effects, Adipogenesis drug effects, Obesity metabolism, 3T3-L1 Cells, Adipocytes drug effects, Adipocytes metabolism, Mice, Inbred C57BL
- Abstract
Background: Overweight, often known as obesity, is the abnormal and excessive accumulation of fat that exposes the health of a person at risk by increasing the likelihood that they may experience many chronic conditions. Consequently, obesity has become a global health threat, presenting serious health issues, and attracting a lot of attention in the healthcare profession and the scientific community., Method: This study aims to explore the anti-adipogenic properties of 7-MEGA™ in an attempt to address obesity, using both in vitro and in vivo research. The effects of 7MEGA™ at three distinct concentrations were investigated in obese mice who were given a high-fat diet (HFD) and 3T3-L1 adipocytes., Results: 7MEGA™ decreased the total fat mass, overall body weight, and the perirenal and subcutaneous white adipose tissue (PWAT and SWAT) contents in HFD mice. Additionally, 7MEGA™ showed promise in improving the metabolic health of individuals with obesity and regulate the levels of insulin hormone, pro-inflammatory cytokines and adipokines. Furthermore, Peroxisome proliferator-activated receptors (PPAR) α and γ, Uncoupling Protein 1 (UCP-1), Sterol Regulatory Element-Binding Protein 1 (SREBP-1), Fatty Acid-Binding Protein 4 (FABP4), Fatty Acid Synthase (FAS), Acetyl-CoA Carboxylase (ACC), Stearoyl-CoA Desaturase-1 (SCD-1) and CCAAT/Enhancer-Binding Protein (C/EBPα) were among the adipogenic regulators that 7MEGA™ could regulate., Conclusion: In summary, this study uncovered that 7MEGA™ demonstrates anti-adipogenic and anti-obesity effects, suggesting its potential in combating obesity., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF