1. B‐cell lymphoma‐3 controls mesenchymal stem cell commitment and senescence during skeletal aging.
- Author
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Wang, Fuxiao, Guo, Jiawei, Wang, Sicheng, Wang, Yili, Chen, Jiao, Hu, Yan, Zhang, Hao, Xu, Ke, Wei, Yan, Cao, Liehu, Chen, Xiao, Jing, Yingying, and Su, Jiacan
- Subjects
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MESENCHYMAL stem cells , *CELLULAR aging , *CELL determination , *AGING , *ADIPOGENESIS , *OLDER people - Abstract
To sum up, Bcl-3 was decreased during BMSCs senescence, and the supply of Bcl-3 could protect BMSCs from aging. Skeletal aging is characterized by progressive bone loss and increased marrow adiposity.1,2 Age-related bone loss impairs the exercise activity of patients and increases the risk of fracture. (F) Bcl-3, Ac-K49- -catenin and -catenin were analysed by immunoblot in control and Bcl-3-knockdown BMSCs after treated with Wnt 3a for 0 h or 4 h. (G) The levels of Bcl-3 in nuclear and cytoplasmic. B-cell lymphoma-3 controls mesenchymal stem cell commitment and senescence during skeletal aging. [Extracted from the article]
- Published
- 2022
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