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Background and Aims: Adiponectin is a peptide hormone secreted by adipocytes and plays a protective role against the development of insulin resistance. Diabetes mellitus, or uncontrolled glycemic level, is one the factors for the failure of dental implant. The study aimed to show the relevance of adiponectin in diabetic patients during dental implants. Materials and Methods: The study was conducted on 152 patients. Out of these, 94 were males and 58 were females, 71 were diabetics following treatment anti-diabetic drugs or on insulin therapy, or on both and 81 were non-diabetics. The anthropometric measurements and the blood pressure were noted and the glycemic and the adiponectin levels were assessed before and after the implant. Results: The study revealed that adiponectin was inversely correlated and it decreased with the increase in body mass index. In comparing the diabetic group with the non-diabetic one, before and after the implant, the average adiponectin was significantly higher in the non-diabetic group (5.03 vs. 2.16, p < 0.001, respectively 5.24 vs. 2.24, p < 0.001). Conclusions: The study concludes that adiponectin is one of the potential biomarkers for the early detection of the development of diabetes and metabolic syndrome and that its low levels might lead to the failure of the dental implant. [ABSTRACT FROM AUTHOR]