1. Cellular and Molecular Players in the Interplay between Adipose Tissue and Breast Cancer.
- Author
-
Reggiani F, Falvo P, and Bertolini F
- Subjects
- Adipose Tissue metabolism, Animals, Breast Neoplasms complications, Breast Neoplasms metabolism, Disease Models, Animal, Disease Progression, Female, Humans, Inflammation complications, Inflammation metabolism, Inflammation pathology, Obesity complications, Obesity metabolism, Tumor Microenvironment, Adipose Tissue pathology, Breast Neoplasms pathology, Obesity pathology
- Abstract
The incidence and severity of obesity are rising in most of the world. In addition to metabolic disorders, obesity is associated with an increase in the incidence and severity of a variety of types of cancer, including breast cancer (BC). The bidirectional interaction between BC and adipose cells has been deeply investigated, although the molecular and cellular players involved in these mechanisms are far from being fully elucidated. Here, we review the current knowledge on these interactions and describe how preclinical research might be used to clarify the effects of obesity over BC progression and morbidity, with particular attention paid to promising therapeutic interventions.
- Published
- 2021
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