1. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
- Author
-
Brandão BB, Madsen S, Rabiee A, Oliverio M, Ruiz GP, Ferrucci DL, Branquinho JL, Razolli D, Pinto S, Nielsen TS, Festuccia WT, Martins AS, Guerra BA, Knittel TL, Søgaard D, Larsen S, Helge JW, Brandauer J, Velloso LA, Emanuelli B, Kornfeld JW, Kahn CR, Vienberg SG, Zierath JR, Treebak JT, and Mori MA
- Subjects
- AMP-Activated Protein Kinases metabolism, Adaptation, Physiological physiology, Adipocytes metabolism, Animals, Cells, Cultured, DEAD-box RNA Helicases deficiency, DEAD-box RNA Helicases genetics, Female, Glycolysis, Humans, Male, Mice, Mice, Knockout, MicroRNAs genetics, MicroRNAs metabolism, Physical Conditioning, Animal, Ribonuclease III deficiency, Ribonuclease III genetics, Adipose Tissue metabolism, DEAD-box RNA Helicases metabolism, Exercise physiology, Ribonuclease III metabolism
- Abstract
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations., Competing Interests: The authors declare no competing interest.
- Published
- 2020
- Full Text
- View/download PDF