1. Adjuvant Chemotherapy in Older Adults With Colon Cancer.
- Author
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Williams, Grant R. and Sanoff, Hanna K.
- Subjects
ANTINEOPLASTIC agents ,ELDER care ,CANCER chemotherapy ,CANCER patient medical care ,COLON tumors ,COMBINED modality therapy ,DECISION making ,DECISION making in clinical medicine ,OLD age - Abstract
Colorectal cancer (CRC) is predominately a disease of older adults, with the median age of diagnosis 68 years; 59% of all cases are diagnosed in persons age 65 years or older. Although older patients have been underrepresented in clinical trials, pooled analysis suggests similar treatment benefits with fluorouracil and leucovorin (5FU/LV) for older patients compared with younger patients, while the evidence of treatment benefit from oxaliplatin-containing regimens is less compelling. Many helpful tools that provide estimates of prognosis, risk of recurrence, risk of severe toxicity with chemotherapy, and functional age can aid clinical decisions. In this review, we present the evidence for adjuvant chemotherapy in older adults, discuss helpful tools that can aid in adjuvant decision making, and present a suggested treatment approach to adjuvant chemotherapy in older adults with CRC. [ABSTRACT FROM AUTHOR]
- Published
- 2015