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Your search keyword '"van den Bergh, ACM"' showing total 2 results
Start Over Author "van den Bergh, ACM" Topic adjuvant radiotherapy
2 results on '"van den Bergh, ACM"'

1. The morbidity of treatment for patients with stage I endometrial cancer: Results from a randomized trial

Author

Creutzberg, CL, van Putten, WLJ, Koper, PC, Lybeert, MLM, Jobsen, JJ, Warlam-Rodenhuis, CC, De Winter, KAJ, Lutgens, LCHW, van den Bergh, ACM, van der Steen-Banasik, E, Beerman, H, van Lent, M, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
COMPLICATIONS, CARCINOMA, BRACHYTHERAPY, acute and late complications, IRRADIATION, POSTOPERATIVE RADIOTHERAPY, EXTERNAL-BEAM, RADIATION-THERAPY, endometrial cancer, PATHOLOGICAL STAGE, adverse effects, randomized trial, HYSTERECTOMY, ADJUVANT RADIOTHERAPY, radiotherapy, treatment-related morbidity
Abstract

Purpose: To compare the treatment complications for patients with Stage I endometrial cancer treated with surgery and pelvic radiotherapy (RT) or surgery alone in a multicenter randomized trial. Methods and Materials: The Postoperative Radiation Therapy in Endometrial Carcinoma (PORTEC) trial included patients with endometrial cancer confined to the uterine corpus, either Grade 1 or 2 with more than 50% myometrial invasion, or Grade 2 or 3 with less than 50% myometrial invasion. Surgery consisted of an abdominal hysterectomy and oophorectomy, without lymphadenectomy. After surgery, patients were randomized to receive pelvic RT (46 Gy), or no further treatment. A total of 715 patients were randomized. Treatment complications were graded using the French-Italian glossary. Results: The analysis was done at a median follow-up duration of 60 months. 691 patients were evaluable. Five-year actuarial rates of late complications (Grades 1-4) were 26% in the RT group and 4% in the control group (p

Published
2001

2. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial

Author

Creutzberg, CL, van Putten, WLJ, Koper, PCM, Lybeert, MLM, Jobsen, JJ, Warlam-Rodenhuis, CC, De Winter, KAJ, Lutgens, LCHW, van den Bergh, ACM, van de Steen-Banasik, E, Beerman, H, van Lent, M, Radiotherapy, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
VAGINAL IRRADIATION, CLINICAL STAGE, TREATMENT FAILURE, PROGNOSTIC FACTORS, EXTERNAL IRRADIATION, RISK-FACTORS, ADENOCARCINOMA, GYNECOLOGIC-ONCOLOGY-GROUP, ADJUVANT RADIOTHERAPY, CANCER
Abstract

Background Postoperative radiotherapy for international Federation of Gynaecology and Obstetrics (FIGO) stage-1 endometrial carcinoma is a subject of controversy due to the low relapse rate and the lack of data from randomised trials. We did a multicentre prospective randomised trial to find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma. Methods Patients with stage-1 endometrial carcinoma (grade 1 with deep [greater than or equal to 50%] myometrial invasion, grade 2 with any invasion, or grade 3 with superficial [ Findings Analysis was done according to the intention-to-treat principle. Of the 715 patients, 714 could be evaluated. The median duration of follow-up was 52 months. 5-year actuarial locoregional recurrence rates were 4% in the radiotherapy group and 14% in the control group (p Interpretation Postoperative radiotherapy in stage-1 endometrial carcinoma reduces locoregional recurrence but has no impact on overall survival, Radiotherapy increases treatment-related morbidity. Postoperative radiotherapy is not indicated in patients with stage-1 endometrial carcinoma below 60 years and patients with grade-2 tumours with superficial invasion.

Published
2000

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