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Your search keyword '"Mikhaĭlova AA"' showing total 11 results
Start Over Author "Mikhaĭlova AA" Topic adjuvants, immunologic
11 results on '"Mikhaĭlova AA"'

1. [Enhancement of measles-mumps divaccine using myelopeptide 2 in experiment].

Author

Liashenko VA, Aleksander SK, Iuminova NV, Mikhaĭlova AA, and Fonina LA

Subjects
Adjuvants, Immunologic administration & dosage, Animals, Antibodies, Viral blood, Drug Evaluation, Preclinical, Female, Guinea Pigs, Immunization Schedule, Immunosuppression Therapy, Injections, Intramuscular, Measles blood, Mumps blood, Oligopeptides administration & dosage, Rats, Vaccines, Combined immunology, Adjuvants, Immunologic pharmacology, Immunization, Measles immunology, Measles Vaccine administration & dosage, Morbillivirus immunology, Mumps immunology, Mumps Vaccine administration & dosage, Mumps Vaccine immunology, Mumps virus immunology, Oligopeptides pharmacology
Abstract

Combined application of mumps and measles vaccine strains in equal doses results in significant decrease of immune response to the former component in humans. It is possible that this phenomenon is related with well-known immunodepressive effect of measles virus, which was demonstrated both in vivo and in vitro. It was previously shown that myelopeptide-2 (MP-2) partially neutralizes suppressive effect of measles vaccine on blast transformation of activated human lymphocytes in vitro. Partial supression of immune response to mumps vaccine by live measles vaccine was reproduced in laboratory animals. It was shown that in experiment MP-2 partially neutralized suppressive effect of measles vaccine.

Published
2007

2. [Endogenous immunoregulatory peptides (myelopeptides): structure, function, and mechanism of action].

Author

Petrov RV, Mikhaĭlova AA, and Fonina LA

Subjects
Adjuvants, Immunologic pharmacology, Amino Acid Sequence, Animals, Cell Differentiation drug effects, Humans, Macrophages drug effects, Macrophages immunology, Phagocytosis drug effects, Structure-Activity Relationship, T-Lymphocytes drug effects, T-Lymphocytes immunology, Tumor Cells, Cultured, Adjuvants, Immunologic chemistry, Oligopeptides chemistry, Oligopeptides pharmacology
Abstract

Previously unknown bioregulators from bone marrow, myelopeptides, were isolated, identified, and synthesized, and their biological properties and mechanism of action were studied in detail. Phe-Leu-Gly-Phe-Pro-Thr (MP-1) manifests an immunocorrecting effect by restoring the level of antibody production in animals suffering from immunodeficiencies of various etiologies; Leu-Val-Val-Tyr-Pro-Trp (MP-2) manifests an antitumor effect by abolishing the inhibitory action of tumor cells on the functional activity of T-lymphocytes; Leu-Val-Cys-Tyr-Pro-Gln (MP-3) stimulates phagocytosis by macrophages and, in this way, protects animals from infections caused by pathogenic microorganisms; and Phe-Pro-Arg-Ile-Met-Thr-Pro (MP-4) is a new factor of cell differentiation inducing terminal cell differentiation in the HL-60 and K-562 leukemic cell lines.

Published
1999

3. [The immunocorrective activity of myelopeptide-1 and myelopeptide-2 in cyclophosphane-treated mice].

Author

Shanurin SIu, Belevskaia RG, Mikhaĭlova AA, and Shanurin MIu

Subjects
Animals, Cell Division, Female, Immunity, Cellular drug effects, Immunization, Lymphocyte Activation drug effects, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Phagocytosis drug effects, Spleen cytology, Spleen drug effects, Adjuvants, Immunologic pharmacology, Bone Marrow immunology, Cyclophosphamide pharmacology, Immunosuppressive Agents pharmacology, Oligopeptides, Peptides pharmacology
Published
1995

4. [Immunoregulatory properties of myelopeptide-1].

Author

Mikhaĭlova AA, Kirilina EA, Shanurin SIu, Fonina LA, Gur'ianov SA, and Petrov RV

Subjects
Amino Acid Sequence, Animals, Cells, Cultured, Female, Lymph Nodes cytology, Lymph Nodes immunology, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Molecular Sequence Data, Spleen cytology, Spleen immunology, T-Lymphocytes, Regulatory immunology, Adjuvants, Immunologic physiology, Oligopeptides, Peptides physiology
Published
1994

5. [Myelopeptides inhibit development of hereditary macrocytic anemia in W/Wv mice].

Author

Petrov RV, Kompaniets NA, Man'ko VM, and Mikhaĭlova AA

Subjects
Anemia, Macrocytic genetics, Anemia, Macrocytic immunology, Animals, Colony-Forming Units Assay, Mice, Mice, Mutant Strains, Adjuvants, Immunologic therapeutic use, Anemia, Macrocytic therapy, Bone Marrow immunology, Oligopeptides, Peptides therapeutic use
Published
1990

6. [Reaction of the blood system to the administration of a bone marrow mediator stimulating antibody production].

Author

Gorizontov PD, Belousova OI, Alferova EM, and Mikhaĭlova AA

Subjects
Animals, Antibody-Producing Cells immunology, Colony-Forming Units Assay, Female, Lymphocytes drug effects, Lymphocytes immunology, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Swine, Time Factors, Adjuvants, Immunologic pharmacology, Antibody-Producing Cells drug effects, Bone Marrow immunology
Published
1984

7. [Effect of a bone marrow stimulator of antibody producers on virus-specific antibody formation in animals infected with flaviviruses].

Author

Petrov RV, Deriabin PG, Sergeev IuO, Loginova NV, and Mikhaĭlova AA

Subjects
Animals, Antibodies, Viral analysis, Antibody Formation drug effects, Immunization, Mice, Mice, Inbred BALB C, Time Factors, Virus Cultivation, Adjuvants, Immunologic pharmacology, Antibodies, Viral biosynthesis, Antibody Specificity drug effects, Bone Marrow immunology, Flavivirus immunology, Togaviridae Infections immunology
Abstract

The injection of the marrow stimulator of antibody-producing cells (SAPC) into animals infected with Japanese encephalitis and tick-borne encephalitis viruses stimulated the formation of virus-specific antibodies in the infected animals, increasing antibody production 8- to 16-fold. Such SAPC-induced stimulation of the formation of virus-specific antibodies is observed in cases of both acute and chronic virus infection. The prospects of using the preparation of SAPC are discussed.

Published
1983

8. [Correction of immune response by myelopeptides in MRL/Mp-lpr/lpr mice with congenital autoimmune disorders].

Author

Petrov RV, Madzhidov UV, Sorokin SV, and Mikhaĭlova AA

Subjects
Animals, Antibody Formation, Autoimmune Diseases congenital, Autoimmune Diseases therapy, Cells, Cultured, Female, Immunization, Lymph Nodes immunology, Male, Mice, Mice, Mutant Strains, Adjuvants, Immunologic, Antibody-Producing Cells immunology, Autoimmune Diseases immunology, Bone Marrow immunology, Oligopeptides, Peptides immunology
Published
1986

10. [B-activin and immunocorrection].

Author

Petrov RV, Stepanenko RN, and Mikhaĭlova AA

Subjects
Animals, Humans, Swine, Activins, Adjuvants, Immunologic analysis, Bone Marrow analysis, Leukemia metabolism, Lymphoma, Non-Hodgkin metabolism, Multiple Myeloma metabolism, Oligopeptides, Peptides analysis
Published
1984

11. [The immunomodulating action of myelopeptides in hypoxic hypoxia in animals].

Author

Sarybaeva DV, Zakharova LA, Vasilenko AM, Mikhaĭlova AA, and Tulebekov BT

Subjects
Adjuvants, Immunologic isolation & purification, Animals, Atmosphere Exposure Chambers, Drug Evaluation, Preclinical, Female, Hypoxia immunology, Immunization, Male, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Molecular Weight, Peptide Biosynthesis, Peptides isolation & purification, Stress, Physiological drug therapy, Stress, Physiological immunology, Adjuvants, Immunologic therapeutic use, Bone Marrow immunology, Hypoxia drug therapy, Oligopeptides, Peptides therapeutic use
Abstract

It was observed that in animals which underwent a hypoxic stress by way of a 3-day exposition in the pressure chamber at an altitude of 7,000 m the immune response to sheep erythrocytes was decreased by 47 per cent. A two-three-fold decrease in the production of myelopeptides was noted in 24h after the exposition in the pressure chamber.

Published
1988

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