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In order to study the effect of adjuvant on improvement of nicosulfuron herbicide efficacy in maize weed control under organic fertilizers application, a field study was conducted during 2013- 2014 at Research Field of Ferdowsi University of Mashhad, Iran. Experiment was arranged in completely randomized design with factorial arrangement of treatments with 16 treatments and three replications. Factors were application of organic fertilizers (cow manure and vermicompost) and bio fertilizer mycorrhiza, and fertilizer free control, nicosulfuron (at two doses of 40, and 80 g a.i ha-1 (Cruz®, 4% SC) with and without the adjuvant of HydroMax™. Common purslane (Portulaca oleracea), black nightshade (Solanum nigrum L.), and redroot pigweed (Amaranthus retroflexus L.) were the dominant weeds in the experimental field. Black nightshade and common purslane had the highest relative density at 20 and 45 days after spraying (DAS). Application of hydromax adjuvant increased herbicide efficiency, significantly. However dry weight of common purslane, black nightshade and redroot pigweed decreased by 84, 71, 86 and 71, 79, 100%, when nicosulfuron applied at the reduced dose (40 g a.i. ha-1) with adjuvant 20 and 45 DAS, respectively. On the other hand, seed yield and dry weight of maize were increased by 49 and 60% respectively, when nicosulfuron applied at 40 g a.i. ha-1 with Hydromax puls cow manure. [ABSTRACT FROM AUTHOR]