12 results on '"Comberiati, Pasquale"'
Search Results
2. Current transition management of adolescents and young adults with allergy and asthma: a European survey
- Author
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Khaleva, Ekaterina, Vazquez-Ortiz, Marta, Comberiati, Pasquale, DunnGalvin, Audrey, Pite, Helena, Blumchen, Katharina, Garriga-Baraut, Teresa, Hox, Valerie, Santos, Alexandra F., Gore, Claudia, Knibb, Rebecca C., Alviani, Cherry, Mortz, Charlotte G., Angier, Elizabeth, Duca, Bettina, Jensen, Britt, Sanchez-Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, Pfaar, Oliver, and Roberts, Graham
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- 2020
- Full Text
- View/download PDF
3. Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study
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Osmanov, Ismail M., Spiridonova, Ekaterina, Bobkova, Polina, Gamirova, Aysylu, Shikhaleva, Anastasia, Andreeva, Margarita, Blyuss, Oleg, El-Taravi, Yasmin, DunnGalvin, Audrey, Comberiati, Pasquale, Peroni, Diego G., Apfelbacher, Christian, Genuneit, Jon, Mazankova, Lyudmila, Miroshina, Alexandra, Chistyakova, Evgeniya, Samitova, Elmira, Borzakova, Svetlana, Bondarenko, Elena, Korsunskiy, Anatoliy A., Konova, Irina, Hanson, Sarah Wulf, Carson, Gail, Sigfrid, Louise, Scott, Janet, Greenhawt, Matthew, Whittaker, Elizabeth A., Garralda, Elena, Swann, Olivia, Buonsenso, Danilo, Nicholls, Dasha E., Simpson, Frances, Jones, Christina, Semple, Malcolm G., Warner, John O., Vos, Theo, Olliaro, Piero, and Munblit, Daniel
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Adolescent ,SARS-CoV-2 ,COVID-19 ,Hospitalized ,Post-COVID-19 condition ,Risk Factors ,Aged ,Child ,Child, Hospitalized ,Female ,Follow-Up Studies ,Humans ,Prospective Studies ,Previously hospitalised children - Abstract
Background: The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.\ud \ud Methods: This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.\ud \ud Findings: 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3–15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and “12–18 years” (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).\ud \ud Interpretation: A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.
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- 2022
4. A practical toolbox for the effective transition of adolescents and young adults with asthma and allergies: An EAACI position paper.
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Vazquez‐Ortiz, Marta, Gore, Claudia, Alviani, Cherry, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Garriga‐Baraut, Teresa, Gowland, M. Hazel, Egmose, Britt, Knibb, Rebecca, Khaleva, Ekaterina, Mortz, Charlotte G., Pfaar, Oliver, Pite, Helena, Podesta, Marcia, Santos, Alexandra F., Sanchez‐Garcia, Silvia, and Timmermans, Frans
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YOUNG adults ,ALLERGIES ,MEDICAL personnel ,ASTHMA ,TEENAGERS - Abstract
Introduction: Adolescence is a critical stage of rapid biological, emotional and social change and development. Adolescents and young adults (AYA) with asthma and allergies need to develop the knowledge and skills to self‐manage their health independently. Healthcare professionals (HCP), parents and their wider network play an essential role in supporting AYA in this process. Previous work showed significant limitations in transition care across Europe. In 2020, the first evidence‐based guideline on effective transition for AYA with asthma and allergies was published by EAACI. Aim: We herein summarize practical resources to support this guideline's implementation in clinical practice. Methods: For this purpose, multi‐stakeholder Task Force members searched for resources in peer review journals and grey literature. These resources were included if relevant and of good quality and were pragmatically rated for their evidence‐basis and user friendliness. Results: Resources identified covered a range of topics and targeted healthcare professionals, AYA, parents/carers, schools, workplace and wider community. Most resources were in English, web‐based and had limited evidence‐basis. Conclusions: This position paper provides a valuable selection of practical resources for all stakeholders to support effective transitional care for AYA with asthma and allergies. Future research should focus on developing validated, patient‐centred tools to further assist evidence‐based transition care. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
- View/download PDF
5. Current transition management of adolescents and young adults with allergy and asthma
- Author
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Khaleva, Ekaterina, Vazquez-Ortiz, Marta, Comberiati, Pasquale, Dunngalvin, Audrey, Pite, Helena, Blumchen, Katharina, Garriga-Baraut, Teresa, Hox, Valerie, Santos, Alexandra F., Gore, Claudia, Knibb, Rebecca C., Alviani, Cherry, Mortz, Charlotte G., Angier, Elizabeth, Duca, Bettina, Jensen, Britt, Sanchez-Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, Pfaar, Oliver, Roberts, Graham, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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Pulmonary and Respiratory Medicine ,Healthcare professional ,Young adult ,Adolescent ,Allergy ,SDG 3 - Good Health and Well-being ,education ,Transition ,Immunology ,Immunology and Allergy ,humanities - Abstract
Background: Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare professionals (HCPs) on transition of these patients and local/national protocols are also mostly lacking. Methods: European HCPs working with AYA with allergy and asthma were invited to complete an online survey assessing challenges of working with these patients, current transition practices and access to specific healthcare resources. Results: A total of 1179 responses from 41 European countries were collected. Most HCPs (86%) reported a lack of a transition guideline and a lack of a transition process (20% paediatric HCPs, 50% of adult HCPs, 56% HCP seeing all ages). Nearly half (48%) acknowledged a lack of an established feedback system between paediatric and adult medical services. Many respondents never routinely asked about mental health issues such as self-harm or depression and are not confident in asking about self-harm (66.6%), sexuality (64%) and depression (43.6%). The majority of HCPs (76%) had not received specific training in the care of AYA although 87% agreed that transition was important for AYA with allergy and asthma. Conclusion: Although there was agreement that transition is important for AYA with allergy and asthma, there are crucial limitations and variations in the current provision of transition services across Europe. Standardisation of AYA management and specific training are required. This should improve management and continuity of care during adolescence and into adulthood to achieve the best healthcare outcomes.[Figure not available: See fulltext.] publishersversion published
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- 2020
6. A systematic review
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Vazquez-Ortiz, Marta, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valérie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez, Silvia, Alviani, Cherry, Garriga-Baraut, Teresa, Knibb, Rebecca, Mortz, Charlotte G., Gowland, M. Hazel, Timmermans, Frans, Roberts, Graham, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)
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food allergy ,SDG 3 - Good Health and Well-being ,adolescent ,Immunology ,rhinoconjunctivitis ,transition ,young adult ,Immunology and Allergy ,asthma ,allergy - Abstract
Background: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta-synthesis was undertaken. Results: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health-related quality of life—impairment was associated with poor disease control, psychosocial issues, adolescent-onset allergic disease and female sex; (b) Psychological factors—asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence—suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self-management—facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships—families could modify barriers to adherence and foster positive views about self-management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals. Conclusions: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents. publishersversion published
- Published
- 2020
7. A systematic review
- Author
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Knibb, Rebecca C., Alviani, Cherry, Garriga-Baraut, Teresa, Mortz, Charlotte G., Vazquez-Ortiz, Marta, Angier, Elizabeth, Blumchen, Katerina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valerie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez-Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, Roberts, Graham, Centro de Estudos de Doenças Crónicas (CEDOC), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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adolescent ,Immunology ,young adult ,Immunology and Allergy ,asthma ,allergy ,interventions - Abstract
Background: This systematic review aimed to review the literature on interventions for improving self-management and well-being in adolescents and young adults (11-25 years) with asthma and allergic conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative synthesis was undertaken. Results: A total of 30 papers reporting data from 27 studies were included. Interventions types were psychological (k = 9); e-health (k = 8); educational (k = 4); peer-led (k = 5); breathing re-training (k = 1). All interventions were for asthma. Psychological interventions resulted in significant improvements in the intervention group compared with the control group for self-esteem, quality of life, self-efficacy, coping strategies, mood and asthma symptoms. E-Health interventions reported significant improvements for inhaler technique, adherence and quality of life. General educational interventions demonstrated significantly improved quality of life, management of asthma symptoms, controller medication use, increased use of a written management plan and reduction in symptoms. The peer-led interventions included the Triple A (Adolescent Asthma Action) programme and a peer-led camp based on the Power Breathing Programme. Improvements were found for self-efficacy, school absenteeism and quality of life. Conclusion: Although significant improvements were seen for all intervention types, many were small feasibility or pilot studies, few studies reported effect sizes and no studies for allergic conditions other than asthma met the inclusion criteria. Research using large longitudinal interventional designs across the range of allergic conditions is required to strengthen the evidence base. publishersversion published
- Published
- 2020
8. EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma.
- Author
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Roberts, Graham, Vazquez‐Ortiz, Marta, Knibb, Rebecca, Khaleva, Ekaterina, Alviani, Cherry, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Garriga‐Baraut, Teresa, Gore, Claudia, Gowland, M. Hazel, Hox, Valérie, Jensen, Britt, Mortz, Charlotte G., Pfaar, Oliver, Pite, Helena, Santos, Alexandra F., and Sanchez‐Garcia, Silvia
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YOUNG adults ,MEDICAL personnel ,TEENAGERS ,TRANSITIONAL care ,ASTHMA ,ALLERGIES - Abstract
Adolescent and young adult (AYA) patients need additional support, while they experience the challenges associated with their age. They need specific training to learn the knowledge and skills required to confidently self‐manage their allergies and/or asthma. Transitional care is a complex process, which should address the psychological, medical, educational and vocational needs of AYA in the developmentally appropriate way. The European Academy of Allergy and Clinical Immunology has developed a clinical practice guideline to provide evidence‐based recommendations for healthcare professionals to support the transitional care of AYA with allergy and/or asthma. This guideline was developed by a multidisciplinary working panel of experts and patient representatives based on two recent systematic reviews. It sets out a series of general recommendations on operating a clinical service for AYA, which include the following: (a) starting transition early (11‐13 years), (b) using a structured, multidisciplinary approach, (c) ensuring AYA fully understand their condition and have resources they can access, (d) active monitoring of adherence and (e) discussing any implications for further education and work. Specific allergy and asthma transition recommendations include (a) simplifying medication regimes and using reminders; (b) focusing on areas where AYA are not confident and involving peers in training AYA patients; (c) identifying and managing psychological and socio‐economic issues impacting disease control and quality of life; (d) enrolling the family in assisting AYA to undertake self‐management; and (e) encouraging AYA to let their friends know about their allergies and asthma. These recommendations may need to be adapted to fit into national healthcare systems. [ABSTRACT FROM AUTHOR]
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- 2020
- Full Text
- View/download PDF
9. The effectiveness of interventions to improve self‐management for adolescents and young adults with allergic conditions: A systematic review.
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Knibb, Rebecca C., Alviani, Cherry, Garriga‐Baraut, Teresa, Mortz, Charlotte G., Vazquez‐Ortiz, Marta, Angier, Elizabeth, Blumchen, Katerina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valerie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez‐Garcia, Silvia, Gowland, M. Hazel, Timmermans, Frans, and Roberts, Graham
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YOUNG adults ,TEENAGERS ,META-analysis ,SCHOOL absenteeism ,PSYCHOLOGICAL typologies ,ALLERGIC conjunctivitis - Abstract
Background: This systematic review aimed to review the literature on interventions for improving self‐management and well‐being in adolescents and young adults (11‐25 years) with asthma and allergic conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative synthesis was undertaken. Results: A total of 30 papers reporting data from 27 studies were included. Interventions types were psychological (k = 9); e‐health (k = 8); educational (k = 4); peer‐led (k = 5); breathing re‐training (k = 1). All interventions were for asthma. Psychological interventions resulted in significant improvements in the intervention group compared with the control group for self‐esteem, quality of life, self‐efficacy, coping strategies, mood and asthma symptoms. E‐Health interventions reported significant improvements for inhaler technique, adherence and quality of life. General educational interventions demonstrated significantly improved quality of life, management of asthma symptoms, controller medication use, increased use of a written management plan and reduction in symptoms. The peer‐led interventions included the Triple A (Adolescent Asthma Action) programme and a peer‐led camp based on the Power Breathing Programme. Improvements were found for self‐efficacy, school absenteeism and quality of life. Conclusion: Although significant improvements were seen for all intervention types, many were small feasibility or pilot studies, few studies reported effect sizes and no studies for allergic conditions other than asthma met the inclusion criteria. Research using large longitudinal interventional designs across the range of allergic conditions is required to strengthen the evidence base. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
10. Understanding the challenges faced by adolescents and young adults with allergic conditions: A systematic review.
- Author
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Vazquez‐Ortiz, Marta, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Gore, Claudia, Hox, Valérie, Jensen, Britt, Pite, Helena, Santos, Alexandra F., Sanchez, Silvia, Alviani, Cherry, Garriga‐Baraut, Teresa, Knibb, Rebecca, Mortz, Charlotte G., Gowland, M. Hazel, Timmermans, Frans, and Roberts, Graham
- Subjects
YOUNG adults ,TEENAGERS ,ADOLESCENCE ,QUALITY of life ,MEDICAL personnel ,ATTITUDES toward sex - Abstract
Background: Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. Methods: A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was assessed in duplicate. A narrative meta‐synthesis was undertaken. Results: A total of 108 papers describing 106 studies were retrieved, most focused on asthma. Five themes were identified across studies: (a) Health‐related quality of life—impairment was associated with poor disease control, psychosocial issues, adolescent‐onset allergic disease and female sex; (b) Psychological factors—asthma and food allergy were associated with anxiety and depression, atopic dermatitis was associated with suicidal ideation, and that parental emotional support may be protective; (c) Adherence—suboptimal adherence was associated with older age, barriers to medication usage, poor symptom perception and failure to take responsibility, and positive factors were routines, simpler treatment regimes, better knowledge and perceptions about medications; (d) Self‐management—facilitated by education, knowledge and a positive attitude; and (e) Supportive relationships—families could modify barriers to adherence and foster positive views about self‐management, adolescents suggested that their peers should be more involved in supporting them, and adolescents also wished to have support from nonjudgemental healthcare professionals. Conclusions: We have some understanding of the challenges faced by adolescents with asthma, less so for other allergic conditions. This knowledge will be used to support guidelines for managing adolescents. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
11. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever
- Author
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Stringari, Giovanna, Tripodi, Salvatore, Caffarelli, Carlo, Dondi, Arianna, Asero, Riccardo, Businco Andrea Di Rienzo, Bianchi, Annamaria, Candelotti, Paolo, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, Giudice Michele Miraglia del, Frediani, Tullio, Sodano, Simona, Iacono Iride Dello, Macrì, Francesco, Peparini, Ilaria, Dascola Carlotta Povesi, Patria Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Matricardi Paolo Maria, Network The Italian Pediatric Allergy, Stringari, Giovanna, Tripodi, Salvatore, Caffarelli, Carlo, Dondi, Arianna, Asero, Riccardo, Di Rienzo Businco, Andrea, Bianchi, Annamaria, Candelotti, Paolo, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, Miraglia Del Giudice, Michele, Frediani, Tullio, Sodano, Simona, Dello Iacono, Iride, Macrì, Francesco, Peparini, Ilaria, Povesi Dascola, Carlotta, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Matricardi, Paolo Maria, and MIRAGLIA DEL GIUDICE, Michele
- Subjects
Male ,Allergy ,component-resolved diagnosis ,Profilin ,Gene Expression ,Immunoglobulin E ,Allergic rhinitis ,Profilins ,Mugwort ,Outpatient clinic ,Immunology and Allergy ,Child ,Sensitization ,panallergens ,biology ,Skin Test ,Allergen ,Medicine (all) ,Plants ,medicine.anatomical_structure ,panallergen ,pollen ,Child, Preschool ,Hay fever ,Cross Reaction ,Female ,IgE ,Allergic rhinitis, children, component-resolved diagnosis, IgE, panallergens, pollen, profilin, specific immunotherapy ,specific immunotherapy ,Human ,medicine.medical_specialty ,Adolescent ,Immunology ,Cross Reactions ,component-resolved diagnosi ,NO ,children ,Internal medicine ,medicine ,Allergic rhiniti ,Humans ,Medical prescription ,Skin Tests ,Settore MED/38 - Pediatria Generale e Specialistica ,business.industry ,Rhinitis, Allergic, Seasonal ,Plant ,Allergens ,medicine.disease ,Desensitization, Immunologic ,biology.protein ,Allergists ,profilin ,business - Abstract
Background Sensitization to profilins and other cross-reacting molecules might hinder proper specific immunotherapy (SIT) prescription in polysensitized patients with pollen-related allergic rhinitis (AR). In these patients, component-resolved diagnosis (CRD) might modify SIT prescription by improving the identification of the disease-eliciting pollen sources. Objectives We sought to measure the effect of CRD on SIT prescription in children with pollen-related AR. Methods Children (n = 651) with moderate-to-severe pollen-related AR were recruited between May 2009 and June 2011 in 16 Italian outpatient clinics. Skin prick test (SPT) reactivity to grass, cypress, olive, mugwort, pellitory, and/or Betulaceae pollen was considered clinically relevant if symptoms occurred during the corresponding peak pollen season. IgE sensitization to Phl p 1, Phl p 5, Bet v 1, Cup a 1, Art v 1, Ole e 1, Par j 2, and Phl p 12 (profilin) was measured by using ImmunoCAP. SIT prescription was modeled on SPT responses first and then remodeled considering also CRD according to GA2LEN-European Academy of Allergology and Clinical Immunology guidelines and the opinions of 14 pediatric allergists. Results No IgE to the respective major allergens was detected in significant proportions of patients with supposed clinically relevant sensitization to mugwort (45/65 [69%]), Betulaceae (146/252 [60%]), pellitory (78/257 [30%]), olive (111/390 [28%]), cypress (28/184 [15%]), and grass (56/568 [10%]). IgE to profilins, polcalcins, or both could justify 173 (37%) of 464 of these SPT reactions. After CRD, the SPT-based decision on SIT prescription or composition was changed in 277 (42%) of 651 or 315 (48%) of 651 children according to the European or American approach, respectively, and in 305 (47%) of 651 children according to the opinion of the 14 local pediatric allergists. Conclusions In children with pollen-related AR, applying CRD leads to changes in a large proportion of SIT prescriptions as opposed to relying on clinical history and SPT alone. The hypothesis that CRD-guided prescription improves SIT efficacy deserves to be tested. © 2014 American Academy of Allergy, Asthma and Immunology.
- Published
- 2014
12. Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort
- Author
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Giovanna De Castro, Paolo Maria Matricardi, Ekaterina Potapova, Pasquale Comberiati, Ifigenia Sfika, Valentina Panetta, Giampaolo Ricci, Salvatore Tripodi, Anna Maria Zicari, Giulia Brindisi, Simone Pelosi, Viviana Moschese, Arianna Giannetti, Roberto Bernardini, Carla Mastrorilli, Francesca Cipriani, Carlo Caffarelli, Andrea Di Rienzo Businco, Michele Miraglia Del Giudice, Serena Perna, Iride Dello Iacono, Rosa Cervone, Marcella Gallucci, Valeria Villella, Antonella Casani, Elena Varin, Loredana Chini, Arianna Dondi, Cipriani, F., Tripodi, S., Panetta, V., Perna, S., Potapova, E., Dondi, A., Bernardini, R., Caffarelli, C., Casani, A., Cervone, R., Chini, L., Comberiati, P., De Castro, G., Miraglia Del Giudice, M., Dello Iacono, I., Di Rienzo Businco, A., Gallucci, M., Giannetti, A., Mastrorilli, C., Moschese, V., Pelosi, S., Sfika, I., Varin, E., Villella, V., Zicari, A. M., Brindisi, G., Ricci, G., Matricardi, P. M., Cipriani, Francesca, Tripodi, Salvatore, Panetta, Valentina, Perna, Serena, Potapova, Ekaterina, Dondi, Arianna, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, De Castro, Giovanna, Miraglia Del Giudice, Michele, Dello Iacono, Iride, Di Rienzo Businco, Andrea, Gallucci, Marcella, Giannetti, Arianna, Mastrorilli, Carla, Moschese, Viviana, Pelosi, Simone, Sfika, Ifigenia, Varin, Elena, Villella, Valeria, Zicari, Anna Maria, Brindisi, Giulia, Ricci, Giampaolo, and Matricardi, Paolo Maria
- Subjects
Male ,Longitudinal study ,Pru p 3 ,Longitudinal Studie ,Immunoglobulin E ,medicine.disease_cause ,Atopy ,Allergen ,Risk Factors ,Surveys and Questionnaires ,Prevalence ,Immunology and Allergy ,Longitudinal Studies ,Prospective Studies ,skin and connective tissue diseases ,Child ,Sensitization ,Rhinitis ,biology ,Skin Test ,longitudinal study ,Bet v 1 ,IgE ,Phl p 1 ,Phl p 5 ,allergic rhinitis ,asthma ,biomarkers ,children ,comorbidities ,pollen ,prediction ,Adolescent ,Allergens ,Asthma ,Biomarkers ,Disease Progression ,Female ,Follow-Up Studies ,Humans ,Italy ,Rhinitis, Allergic ,Skin Tests ,medicine.anatomical_structure ,Cohort ,allergic rhiniti ,Human ,medicine.medical_specialty ,comorbiditie ,Immunology ,Follow-Up Studie ,Allergic ,Oral allergy syndrome ,Internal medicine ,medicine ,Settore MED/38 - Pediatria Generale e Specialistica ,business.industry ,Risk Factor ,fungi ,Biomarker ,medicine.disease ,body regions ,Prospective Studie ,Pediatrics, Perinatology and Child Health ,biology.protein ,business - Abstract
Background: Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large cohort of children with SAR. Methods: During 2015-2017 (follow-up), we re-examined 401 patients from those enrolled in 2009-2011 (baseline) by the “Panallergens in Pediatrics” study, a large multicenter survey of Italian children with SAR. Information on clinical history (standard questionnaire, AllergyCARD®; TPS, Italy) and skin prick tests for inhalant and foods extracts (ALK-Abelló, Hørsholm, Denmark) was acquired as at baseline visit. Evolution in clinical and sensitization data of patients was analyzed over time, as well as their association with the main baseline characteristics and atopy risk factors. Results: The average age of participants was 10.4±3.4years at baseline and 16.2±3.6years at follow-up. SAR persisted in 93.3% of patients at follow-up and became more frequently associated with asthma (from 36.7% at baseline to 48.6% at follow-up) and oral allergy syndrome (OAS, from 23.4% to 37.7%). Compared to baseline, the prevalence of skin sensitization to some pollens (Phleum pratense, Corylus avellana, Platanus acerifolia, Artemisia vulgaris) and vegetables (hazelnut, wheat, and apple) significantly decreased at follow-up. Earlier onset of SAR and polysensitization at baseline were associated with incident asthma at follow-up. The presence at baseline of serum IgE to the following allergen molecules was identified as biomarkers of clinical evolution: (a) Phl p 1, for persistence of SAR; (b) Phl p 5, for persistence of both rhinitis and asthma; (c) Pru p 3, for new onset of asthma; (d) Bet v 1, for persistence of OAS. Conclusions: Seasonal allergic rhinoconjunctivitis is clinically heterogeneous in its evolution from childhood to adolescence. The detection of serum IgE to specific molecules (Phl p 1, Phl p 5, Bet v 1, Pru p 3) may be useful as biomarkers to predict SAR persistence and future onset of comorbidities, such as asthma and/or OAS.
- Published
- 2018
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