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Histopathological effects of Diazinon (DZ) were studied on adrenal gland in virgin young female mice divided into five groups (10 animals each): (1) Control (untreated); (2) and (3) 9 and 18 mg kg−1 single exposure groups (given distilled water on day 1 and 2 and DZ on day 3); (4) and (5) 9 and 18 mg kg−1 multiple exposure groups (given respective DZ doses on days 1–3). All doses were applied by gavage. Animals were euthanized by cervical dislocation on day 6. Adrenals were removed surgically for histological and micrometric assessments of medulla and cortex. Histological examination of adrenal medulla revealed apoptotic changes and granular depletion in chromaffin cells while cortex gave impression of increased thickness of Zona Fasciculata following multiple DZ exposures. Mean cell sizes in cortical and medullary regions showed dose and exposure dependent significant decline. In conclusion, DZ exposure caused granular depletion in chromaffin cells indicating a rapid release of adrenaline and increased f...