1. Alpha adrenergic antagonism by cyclosporine.
- Author
-
Parkhurst GW, Prancan AV, and Moon BH
- Subjects
- Animals, Blood Pressure drug effects, Dose-Response Relationship, Drug, Heart Rate drug effects, Phenylephrine pharmacology, Rabbits, Adrenergic alpha-Antagonists pharmacology, Cyclosporins pharmacology, Receptors, Adrenergic, alpha drug effects
- Abstract
Cyclosporine has been shown to exert antiadrenergic actions in previous studies from this laboratory. Interactions of CsA with the alpha-one and alpha-two receptor were studied in rabbits. Blood pressure studies revealed that CsA exerts a competitive, reversible antagonism against norepinephrine, epinephrine, and phenylephrine. Further studies of heart rate depression by clonidine also demonstrated that CsA antagonizes this action. In conclusion, cyclosporine appears to act as a nonspecific alpha antagonist.
- Published
- 1991
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