1. The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea.
- Author
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Wu AH, Tabas J, Stein J, Potocki M, Mueller C, McCord J, Richards M, Hartmann O, Nowak R, Peacock WF, Ponikowski P, Moeckel M, Hogan C, Filippatos GS, Di Somma S, Anand I, Ng L, Neath SX, Christenson R, Morgenthaler NG, Anker SD, and Maisel AS
- Subjects
- Acute Disease, Adult, Aged, Aged, 80 and over, Biomarkers blood, Clinical Trials as Topic, Diabetes Mellitus diagnosis, Diabetes Mellitus mortality, Dyspnea blood, Dyspnea mortality, Female, Heart Failure blood, Heart Failure mortality, Humans, Kaplan-Meier Estimate, Linear Models, Male, Middle Aged, Multivariate Analysis, Prognosis, ROC Curve, Adrenomedullin blood, Atrial Natriuretic Factor blood, Diabetes Mellitus blood, Dyspnea diagnosis, Heart Failure diagnosis, Peptide Fragments blood, Protein Precursors blood
- Abstract
Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.
- Published
- 2012
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