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The safety profile and effectiveness of existing anti-HER2-targeted therapies have not been evaluated in patients with breast cancer and visceral crisis. We report the case of a 26-year-old woman who was diagnosed with advanced HER2-positive breast cancer and initially treated with curative intent therapy in a neoadjuvant setting, using Trastuzumab and Pertuzumab in combination with Docetaxel; her cancer recurred two years later, with liver metastases and pulmonary lymphangitic carcinomatosis, causing visceral crisis. Furthermore, the patient’s clinical status worsened when she developed respiratory failure, hepatomegaly and a severe hepatocytolysis. Since the patient was free of disease more than six months, we started with Paclitaxel half dose because of the hepatic dysfunction, and we gradually reintroduced Trastuzumab and then Pertuzumab. In the meantime, the patient changed her lifestyle by increasing her consumption of fresh fruits and vegetables and fiber and reducing her intake of processed meat, dairy and sugar. As a result, the patient showed a significant improvement in her respiratory symptoms and liver tests in less than two months. Imaging reevaluation showed partial remission of liver metastases and pulmonary lymphangitic carcinomatosis. She underwent seven months of dual anti-HER2 blockade before relapsing cerebrally. Our results suggest that the sequential combination therapy with Trastuzumab, Pertuzumab and Paclitaxel presented in this study, associated with a healthy lifestyle, may be a good management for recurrent HER2-positive breast cancer with pulmonary visceral crisis and severe liver dysfunction.

The research investigated the feeling of sadness, suicidal thoughts and plans associated with binge drinking among students in Timis County, Romania.We applied a transversal population study to the representative sample of 2076 students, 62.49% girls and 37.51% boys with a mean age of 21.09 years with SD 1.48.The boys practice binge drinking significantly more often than girls, the difference is small to medium: prevalence of 22.1% for boys and 8.7% girls, 1-2 times in the last month.Only girls who practice this behavior, increased frequency of engaging in binge drinking is associated with feelings of sadness, suicidal thoughts and suicide plans in a small measure, but significant.

In our study we investigated whether there is a relation between the degree of discontent in relations with the proximal social environment (family and peer groups) and adolescent personality features. The study was conducted on a statistical representative and homogenous sample consisting of 2908 teenagers (51.5% girls and 48.5 % boys, aged between 15 and 19 years). It was an observational (case) study and it consisted in 2 questionnaires applying: Freiburg Personality Inventory (212 items) and CORT 2004 questionnaire (116 items, 6 referring to the discontent levels created by proximal social environment). Cronbach's alpha index was 0.802 for FPI and 0,910 for CORT 2004. Statistical analysis was performed by SPSS 16 program applying Chi square (χ2) and gamma (γ) correlation.Depression and Emotional lability correlated positively and powerfully with q15 (discontent degree of relations with present friend-peers) (γ = 0.471, Sig. 0.000, and γ = 0.383, Sig. 0.000, respectively) and q5 (discontent degree of the relation with parents) (γ = 0.380, Sig. 0.000, and γ = 0.337, Sig. 0.000, respectively). Sociability and calm correlated negative with q5 (γ = -0.14, Sig. 0.000, and γ = -0.35, Sig. 0.000, respectively), q15 (γ = -0.33, Sig. 000 and γ = -0.18, Sig. 000, respectively). In conclusion, there is direct proportional relation between the discontent degree of relations with friend-peers and parents and depression and emotional lability, and inverse proportional relation of friend-peers and parents with sociability and calm.

In the study we conducted we aimed at investigating the relation between personality profiles and risk diet behaviors in teenagers. This study was a case-control one and we applied 2 questionnaires (Freiburg Personality Inventory--FPI with 212 items) and CORT 2004 (items Q94-Q116 of diet behavior) on a sample of 2908 teenagers (51.5% girls and 48.5% boys). Cronbach's alpha index was 0.802 for FPI and 0.730 for items Q101-Q109 of CORT. Personality profiles were built by an Excel 2003 Program. Statistical analysis was realized with SPSS 16 program applying Chi square (chi2) and gamma (gamma) correlation. Personality features of teenagers with high and without risk diet behavior were analyzed. Results obtained: personality profiles and statistical results indicated the existence of a significant statistical difference of aggressiveness and domination between teenagers with high and no consumption of butter and/or lard (Q103) (chi2 = 6.872, Sig. 0.032 and chi2 = 6.922, Sig. 0.031 respectively), of juices from the market (Q106) (chi2 = 9.055, Sig. 0.011 and chi2 = 14.571, Sig. 0.001 respectively). Aggressiveness correlated with consumption of fried potatoes (Q109) (chi2 = 6.144, Sig. 0.046) too. Correlation gamma indicated direct proportional relations of aggressiveness with: Q103 (gamma = 0.215, Sig. 0.017), Q106 (gamma = 0.224, Sig. 0.004), Q109 (gamma = 0.242, Sig. 0.012); and of domination with: Q103 (gamma = 0.234, Sig. 0.008), Q106 (gamma = 0.073, Sig. 0.000). In conclusion, there is a direct proportional relation between consumption of: butter/lard, juices from the market and teenagers' aggressiveness, domination; and a similar relation between consumption of fried potatoes and aggressiveness.

The purpose of this paper is to analyze the self-perception of weight in relation with the body mass index and the body composition of three working groups composed of physically untrained young students, young athletes and patients diagnosed with chronic diseases. The working groups consisted of 110 participants: untrained students, athletes and dialysed patients; 50.9% women and 49.1% men; with an average age of 26.03. The BMI of the patients is significantly higher than the BMI of the athletes and untrained students. No significant differences were found between groups in terms of self-perception of weight. Compared to the physically untrained students and patients, the athletes have a significantly higher level of muscle tissue. The athletes also have a significantly lower adipose tissue than that of the physically untrained students and patients.

The aim of this study is to analyze the infection risk through spatter and aerosolization during scaling and to create a prediction model of the total number of hemolytic bacteria.Air samples were collected prior to patient's arrival and spatter and aerosol samples were collected during scaling procedure in 80 patients of 4 different dental clinics. The dentists calculated DI, CI, DMFT. Only patients with CI= 1 were included. The bacteriological results (CFU/m3) were correlated with clinical indicators. Patients were divided into 2 groups: one that rinse with sterile water and the other with chlohexidine mouth rinse 0.1%.Medium size effect positive correlations were found between the number of decayed teeth and the total number of bacteria and the total number of hemolytic bacteria that grew on plate attached to the dentist's mask. The mean number of bacteria and the mean number of hemolytic bacteria that grew on plate attached to the dentist's mask were significantly lower in the group that rinse with chlorhexidine 0.1%, when compared to the group that rinsed with sterile water. When controlling for the total number of bacteria and the total number of hemolytic bacteria from air sampling, the total number of hemolytic bacteria that grew on the plate attached to the dentist's mask can be predicted by CI, group membership and DMFT score.

The family has a permanent partner role on adolescents till adult stage. The adolescent builds up his own identity based on the affiliation to his family, but he gets away from his family for the need of leading his own life and finding his place in society. The adolescent sample was made up of 2908 college students from Timis County, aged between 15-19 years, 51.5% girls and 48.5% boys. The working method was the populational transversal study based on anonymous self-administration of the investigation questionnaire CORT 2004 about the risky comportment in teenagers, in a CNCSIS research project.The study results high lighten the predominance of family organized affiliation, 78.9% living with family, 88.6%; the medium study level of 63.7% of mothers and 59.1% of fathers; the satisfaction towards family members, 71.7%; satisfaction towards family's financial level, 61.2%. In this way is underlined the role of identity development in adolescents.

The study aimed for a hierarchy of factors associated to the heavy smoker status in young people.The representative sample of students included into the study totalized 2076 young subjects in Timis County universities, with urban residence, 62.5% girls and 37.5% boys, aged between 18-25 years. The working method was the transversal population study based on the CORT 2004 questionnaire regarding health risk behaviors in adolescents and young people. Data processing used the Epilnfo software. The strongest predictors of the heavy smoker status in young people are the existence of suicidal thoughts, the increased number of friends who smoke the smoker status without the wish to quit.Students with an increased intensity of smoking more frequently experienced suicidal thoughts as compared to students smoking with a medium intensity. Students with a medium smoking intensity have significantly more friends who smoke as compared to students who are light smokers. Students, who tried to quit smoking, smoke significantly less cigarettes a day than those who did not wish to quit smoking.

Dietary patterns present at the age of the young adult have great probability to remain unchanged for the rest of the life and may contribute to eating disorders later in life. The aim of this study is the analysis of the intake patterns for fruits and vegetables in students from Timis County.We conducted a cross sectional study using a stratified cluster sample design to produce a representative sample of students for the Timis County. The students' sample totalized 2076 students from the universities in Timis County.A large percent of the young people participating in the study (41.9%) does not consume fresh juices. For the consumption of fresh fruits, the present results back up the international di scoveries, only 32.8% of the young people consuming fruits daily, which is a smaller percent that the medium value reported by other countries. The frequency of consumption for fruits differs according to gender, being higher for girls. For salads, the percent of young people consuming this type of foods at least once a day is 17.0%, much lower compared to 32.8% of the young people consuming fresh fruits at least once a day.The examination of the dietary patterns related to the intake of fruits and vegetables helped us to determine priority areas for future interventions.

In the study we wanted to reveal the distribution of the food borne diseases in Timisoara county, in the period of time 2002-2003. As material we used a sample formed from 142 patients with admissions in the "Victor Babeş" Infectious Diseases Hospital Timişoara, Romania, and the method, epidemiological longitudinal descriptive inquiry, consisted in data registration of the primary evidences (observation files) of the patients. The obtained results revealed: the greater incidence of the food borne diseases in male than female sex; the highest incidence at the age group 15-44 years; the main causal agent as Salmonella group D followed by group B; the greatest frequencies of the food borne diseases in the areas Lipova, Circumvalatiunii and Students Complex of Timişoara. As conclusion, it can be affirmed that food borne diseases are a problem for Timisoara, and for the most cases the causal agent has not been identified.

In the human feeding an important role is realized by the feeding customs, not always being related with a healthy feeding. In our study we wanted to realize a qualitative and quantitative estimation of the nutritive factors in Timişoara medical students food intake. As method we used nourishment investigation with a feeding notebook (the memory technique), distributed individually, 7 days consequently in a sample formed from 50 students of Timişoara Medical School, sample which was homogenous and statistically representative. We realized analysis and statistically interpretation of data. Obtained results: The average values per consumer and day of the nutritive factors of feeding were: proteins--78.4 g, fats--83.3 g, carbohydrates--274.4 g, minerals (macro elements: potassium--2.7 g, calcium--0.5 g, magnesium--0.2 g, phosphorus--1.4 g, chlorine--3.6 g and microelements: iron--17 mg, iodine--0.15 mg, fluoride--2.3 mg, copper--3.6 mg). Vitamins (fat-soluble: A--1370 u.i. D--43.6 u.i,. E--7 mg, K--6300 uDam and hydro soluble: B1--1.1 mg, B2--1.1 mg, B6--2.5 mg, C--39.1 mg, PP--19.3 mg). Average energetic intake per consumer and day was 2244 calories. In conclusion, in the medical students feeding in Timişoara there is a decreased intake of proteins,carbohydrates, a little increased intake of fats, decreased energetic intake, an increased intake of potassium, decreased of calcium, increased of iron, fluoride and copper, decreased of A, D, C vitamins.

This report aims to assess the epidemiological characteristics of cystic echinococcosis (CE) in the largest Romanian county (Timis County). Our study group included 182 patients diagnosed with this condition during 2004–2010. The yearly detection rate of new cases was 3.8 cases per 100 000 inhabitants. People over 40 years old accounted for 52.7% of cases. The incidence was higher in women and in rural inhabitants. No statistically significant decline in the number and incidence of CE cases was observed throughout the study period ( R 2 = 0.24, p 0.3). Consequently, more efficient implementation of correct public health measures is required to fully prevent and eradicate CE in this region.