1. Effects of 4-week mindfulness training versus adaptive cognitive training on processing speed and working memory in multiple sclerosis
- Author
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Ruchika Shaurya Prakash, Heena R. Manglani, Brittney Schirda, Jacqueline Nicholas, and Shaadee Samimy
- Subjects
Adult ,Male ,medicine.medical_specialty ,Mindfulness ,Multiple Sclerosis ,Paced Auditory Serial Addition Test ,Short-term memory ,Neuropsychological Tests ,050105 experimental psychology ,law.invention ,Physical medicine and rehabilitation ,Cognition ,Randomized controlled trial ,law ,medicine ,Reaction Time ,Humans ,0501 psychology and cognitive sciences ,medicine.diagnostic_test ,Working memory ,05 social sciences ,Neuropsychology ,Middle Aged ,Cognitive training ,Neuropsychology and Physiological Psychology ,Memory, Short-Term ,Treatment Outcome ,Female ,Psychology - Abstract
Objective The aim of this preregistered, secondary analysis of a pilot randomized controlled trial (NCT02717429) was to compare the impact of 4-week mindfulness-based training and adaptive cognitive training, with a waitlist control condition, on processing speed and working memory in people with multiple sclerosis (PwMS). Method Sixty-one PwMS were randomized to mindfulness-based training (MBT), adaptive computerized cognitive training (aCT), or a waitlist (WL) control group and completed the Brief Repeatable Battery of Neuropsychological Tests at pre- and posttraining. Training-related changes on the Symbol Digit Modalities Test (SDMT) and the Paced Auditory Serial Addition Test (PASAT) were the primary outcomes of interest. Baseline cognitive status was examined as a moderator of treatment gains. Practice time, change in aCT game difficulty, and rate of change in state awareness across MBT were assessed as correlates of cognitive gains. Findings Compared with aCT and WL, mindfulness training significantly improved processing speed (ηp² = .14). Baseline cognitive status did not moderate change in processing speed (ηp² = .005) or working memory (ηp² = .014). Practice time and change in game difficulty were not significantly correlated with cognitive gains (all ps > .49). In the MBT group, rate of change in awareness was significantly associated with improvement in working memory (ρ = .52, p = .04). Conclusions In PwMS, 4 weeks of mindfulness meditation training improved processing speed above and beyond aCT and WL. More rapid change in awareness during mindfulness training may be associated with greater gains in working memory. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
- Published
- 2020