1. Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients
- Author
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Sven Schippling, Matthias Naegele, Mireia Sospedra, Kati Tillack, Klaus-Peter Wandinger, Roland Martin, and Cathleen Haueis
- Subjects
Adult ,Male ,Multiple Sclerosis ,Neutrophils ,Immunology ,Disease ,Neutrophil Activation ,Pathogenesis ,medicine ,Humans ,Immunology and Allergy ,Aged ,Autoimmune disease ,Neutrophil priming ,Sex Characteristics ,business.industry ,Multiple sclerosis ,Neutrophil extracellular traps ,Middle Aged ,medicine.disease ,Neurology ,Relapsing remitting ,Female ,Neurology (clinical) ,Extracellular Space ,business - Abstract
Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.
- Published
- 2013
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