1. Hypervolemia for Hypertension Pathophysiology: A Population-Based Study
- Author
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Cihan Ural, Ender Hur, Cagatay Buyukuysal, Melih Özişik, Kemal Magden, Kenan Ates, Soner Duman, Sennur Kose, Gultekin Suleymanlar, Gürsel Yildiz, Ibrahim Yildirim, Furuzan Kokturk, Zonguldak Bülent Ecevit Üniversitesi, and Ege Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Article Subject ,Adolescent ,Turkey ,Population ,Statistics as Topic ,Water-Electrolyte Imbalance ,lcsh:Medicine ,Blood Pressure ,Comorbidity ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Young Adult ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Intravascular volume status ,Humans ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,Creatinine ,General Immunology and Microbiology ,business.industry ,Incidence ,lcsh:R ,General Medicine ,Middle Aged ,medicine.disease ,Causality ,Blood pressure ,Endocrinology ,chemistry ,Pathophysiology of hypertension ,Hypertension ,Cardiology ,Female ,Hypervolemia ,business ,Body mass index ,Research Article - Abstract
WOS: 000340761700001, PubMed ID: 25177700, Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 +/- 12.6 (18-89) years, systolic blood pressure (SBP) 134.7 +/- 20, diastolic blood pressure 77.9 +/- 11.6 mmHg. Body mass index (BMI) was 28.5 +/- 4.5 (15.8-50.6) kg/m(2); overhydration was 0.05 +/- 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140 mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension.
- Published
- 2014