1. Severe Hypercalcemia Associated With Uterine Leiomyoma in Pregnancy
- Author
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Edward Tarnawa, Laura Spruill, Scott Sullivan, Mary S. Richardson, and Paul B. Underwood
- Subjects
Adult ,medicine.medical_specialty ,Critical Care ,Pamidronate ,Severity of Illness Index ,Gynecologic Surgical Procedures ,Calcitriol ,Pregnancy ,Severity of illness ,medicine ,Humans ,neoplasms ,Gynecology ,Uterine leiomyoma ,Diphosphonates ,Leiomyoma ,Parathyroid hormone-related protein ,business.industry ,Metabolic disorder ,Infant, Newborn ,Parathyroid Hormone-Related Protein ,Obstetrics and Gynecology ,medicine.disease ,female genital diseases and pregnancy complications ,body regions ,Treatment Outcome ,surgical procedures, operative ,Uterine Neoplasms ,Hypercalcemia ,Pelvic tumor ,Gestation ,Calcium ,Female ,business ,Pregnancy Complications, Neoplastic - Abstract
Uterine leiomyomas are the most common pelvic tumor, and a frequent indication of the need for gynecologic surgery. Although usually asymptomatic, life-threatening cases can occur. We present a case of critical hypercalcemia associated with a leiomyoma during pregnancy with the intention of highlighting the endocrinology of leiomyomas, features shared with malignant neoplasms, and the potential for effects on obstetric outcomes.A 32-year-old gravid woman with a large leiomyoma presented at 33 5/7 weeks of gestation with critical hypercalcemia requiring intensive care. Postpartum myomectomy cured her hypercalcemia, which was driven by parathyroid hormone-related protein (PTHrP) produced by the tumor.Obstetricians should be aware of the existence of humoral hypercalcemia related to leiomyomas and the potential effects on pregnancy.
- Published
- 2011
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