1. A cross-sectional study evaluating hospitalization rates for chronic limb-threatening ischemia during the COVID-19 outbreak in Campania, Italy
- Author
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Ilaria Ficarelli, Luigi Salemme, Rosario Mancusi, Eugenio Stabile, Loris Flora, Raffaele Pio Ammollo, Emilio Soreca, Daniela Viola, Paolo Sangiuolo, Enrico Cappello, Giovanni Esposito, Giovanni Cioffi, Raffaella Niola, Gennaro Vigliotti, Danilo Barbarisi, Angelo Cioppa, Umberto Bracale, Eugenio Laurenzano, Mario De Laurentis, Alfonsina M Corbisiero, Eugenio Martelli, Giancarlo Accarino, Carlo Ruotolo, Claudio Molino, Giampaolo Amabile, Gianpaolo Santini, Alessandro Luongo, Antonio D'angelo, Bruno Villari, Giuseppe Sarti, Adolfo Crinisio, Gianluca Cangiano, Pietro Landino, Claudia De Gregorio, Fernando Petrosino, Raffaele Piccolo, Davide Razzano, Michele Franzese, Stabile, E., Piccolo, R., Franzese, M., Accarino, G., Bracale, U. M., Cappello, E., Cioffi, G., Cioppa, A., Crinisio, A., Flora, L., Landino, P., Martelli, E., Mancusi, R., Niola, R., Petrosino, F., Razzano, D., Ruotolo, C., Salemme, L., Sangiuolo, P., Santini, G., Soreca, E., Vigliotti, G., Villari, B., Amabile, G., Ammollo, R. P., Barbarisi, D., Corbisiero, A. M., D'Angelo, A., Cangiano, G., De Gregorio, C., De Laurentis, M., Laurenzano, E., Ficarelli, I., Luongo, A., Molino, C., Sarti, G., Viola, D., and Esposito, G.
- Subjects
medicine.medical_specialty ,Cross-sectional study ,medicine.medical_treatment ,Ischemia ,cross-sectional studies ,ischemia ,030204 cardiovascular system & hematology ,Rate ratio ,Revascularization ,COVID-19 ,chronic limb-threatening ischemia (CLTI) ,peripheral artery disease (PAD) ,adult ,aged ,aged, 80 and over ,chronic disease ,extremities ,female ,hospitalization ,humans ,italy ,male ,middle aged ,peripheral arterial disease ,retrospective studies ,risk factors ,SARS-CoV-2 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,80 and over ,030212 general & internal medicine ,Peripheral artery disease (PAD) ,Aged, 80 and over ,business.industry ,Outbreak ,Original Articles ,medicine.disease ,Amputation ,Population study ,Cardiology and Cardiovascular Medicine ,business - Abstract
The expansion of coronavirus disease 2019 (COVID-19) prompted measures of disease containment by the Italian government with a national lockdown on March 9, 2020. The purpose of this study is to evaluate the rate of hospitalization and mode of in-hospital treatment of patients with chronic limb-threatening ischemia (CLTI) before and during lockdown in the Campania region of Italy. The study population includes all patients with CLTI hospitalized in Campania over a 10-week period: 5 weeks before and 5 weeks during lockdown ( n = 453). Patients were treated medically and/or underwent urgent revascularization and/or major amputation of the lower extremities. Mean age was 69.2 ± 10.6 years and 27.6% of the patients were women. During hospitalization, 21.9% of patients were treated medically, 78.1% underwent revascularization, and 17.4% required amputations. In the weeks during the lockdown, a reduced rate of hospitalization for CLTI was observed compared with the weeks before lockdown (25 vs 74/100,000 inhabitants/year; incidence rate ratio: 0.34, 95% CI 0.32โ0.37). This effect persisted to the end of the study period. An increased amputation rate in the weeks during lockdown was observed (29.3% vs 13.4%; p < 0.001). This study reports a reduced rate of CLTI-related hospitalization and an increased in-hospital amputation rate during lockdown in Campania. Ensuring appropriate treatment for patients with CLTI should be prioritized, even during disease containment measures due to the COVID-19 pandemic or other similar conditions.
- Published
- 2021