1. Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy
- Author
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Edgar A. DeYoe, Elizabeth A. Felton, Gyujoon Hwang, Anny Reyes, Vivek Prabhakaran, Cole J. Cook, Camille Garcia-Ramos, Rama Maganti, Erik Kaestner, Lisa L. Conant, Candida Ustine, Linda Allen, Veronica N. Sosa, Manoj Raghavan, Umang Shah, Veena A. Nair, Jedidiah Mathis, Andrew S. Nencka, Dace Almane, Mary E. Meyerand, Jeffrey R. Binder, Rasmus M. Birn, Karina Arkush, Charlene N. Rivera Bonet, Kevin Dabbs, Bruce P. Hermann, Aaron F. Struck, and Carrie R. McDonald
- Subjects
Male ,Comorbidity ,Neuropsychological Tests ,Audiology ,lcsh:RC346-429 ,Epilepsy ,Cognition ,0302 clinical medicine ,Neuropsychological assessment ,CI, Cognitive Impairment ,medicine.diagnostic_test ,05 social sciences ,Regular Article ,Neuropsychological test ,Temporal lobe epilepsy (TLE) ,Magnetic Resonance Imaging ,Phenotype ,Cognitive impairment ,Neurology ,Socioeconomic status ,Connectome ,lcsh:R858-859.7 ,Female ,ICV, Intra-Cranial Volume ,ECP, Epilepsy Connectome Project ,psychological phenomena and processes ,Adult ,medicine.medical_specialty ,rs-fMRI, Resting State Functional MRI ,Cognitive Neuroscience ,lcsh:Computer applications to medicine. Medical informatics ,behavioral disciplines and activities ,050105 experimental psychology ,Temporal lobe ,SES, Socio-Economic Status ,03 medical and health sciences ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,lcsh:Neurology. Diseases of the nervous system ,TLE, Temporal Lobe Epilepsy ,business.industry ,medicine.disease ,nervous system diseases ,nervous system ,Epilepsy, Temporal Lobe ,HCP, Human Connectome Project ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Highlights • Cognitive impairment is a major comorbidity of temporal lobe epilepsy (TLE). • Three discrete cognitive phenotypes of TLE are identified here. • The phenotypes are linked to network, clinical, and socioeconomic characteristics. • This taxonomy advances clinical and theoretical understanding of the cognitive complications of TLE., This study explored the taxonomy of cognitive impairment within temporal lobe epilepsy and characterized the sociodemographic, clinical and neurobiological correlates of identified cognitive phenotypes. 111 temporal lobe epilepsy patients and 83 controls (mean ages 33 and 39, 57% and 61% female, respectively) from the Epilepsy Connectome Project underwent neuropsychological assessment, clinical interview, and high resolution 3T structural and resting-state functional MRI. A comprehensive neuropsychological test battery was reduced to core cognitive domains (language, memory, executive, visuospatial, motor speed) which were then subjected to cluster analysis. The resulting cognitive subgroups were compared in regard to sociodemographic and clinical epilepsy characteristics as well as variations in brain structure and functional connectivity. Three cognitive subgroups were identified (intact, language/memory/executive function impairment, generalized impairment) which differed significantly, in a systematic fashion, across multiple features. The generalized impairment group was characterized by an earlier age at medication initiation (P
- Published
- 2020
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