1. Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in
- Author
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Rhian S, Convery, Martina, Bocchetta, Caroline V, Greaves, Katrina M, Moore, David M, Cash, John, Van Swieten, Fermin, Moreno, Raquel, Sánchez-Valle, Barbara, Borroni, Robert, Laforce, Mario, Masellis, Maria Carmela, Tartaglia, Caroline, Graff, Daniela, Galimberti, James B, Rowe, Elizabeth, Finger, Matthis, Synofzik, Rik, Vandenberghe, Alexandre, de Mendonca, Fabrizio, Tagliavini, Isabel, Santana, Simon, Ducharme, Christopher, Butler, Alex, Gerhard, Johannes, Levin, Adrian, Danek, Markus, Otto, Jason D, Warren, Jonathan D, Rohrer, and S, Anderl-Straub
- Subjects
Adult ,Cerebral Cortex ,Male ,DNA Repeat Expansion ,C9orf72 Protein ,Prefrontal Cortex ,Pain Perception ,tau Proteins ,Middle Aged ,Magnetic Resonance Imaging ,Corpus Striatum ,Temporal Lobe ,Cohort Studies ,Perceptual Disorders ,Logistic Models ,Progranulins ,Thalamus ,Cerebellum ,Frontotemporal Dementia ,Asymptomatic Diseases ,Mutation ,Humans ,Female ,Atrophy ,Aged - Abstract
Frontotemporal dementia (FTD) is typically associated with changes in behaviour, language and movement. However, recent studies have shown that patients can also develop an abnormal response to pain, either heightened or diminished. We aimed to investigate this symptom in mutation carriers within the Genetic FTD Initiative (GENFI).Abnormal responsiveness to pain was measured in 462 GENFI participants: 281 mutation carriers and 181 mutation-negative controls. Changes in responsiveness to pain were scored as absent (0), questionable or very mild (0.5), mild (1), moderate (2) or severe (3). Mutation carriers were classified intoAltered responsiveness to pain was present to a significantly greater extent in symptomaticChanges in pain perception are a feature of
- Published
- 2020