1. Peripheral Arterial Disease and Spinal Cord Injury
- Author
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Su, Ta-Wei, Chou, Tzu-Yi, Jou, Herng-Jeng, Yang, Pei-Yu, Lin, Cheng-Li, Sung, Fung-Chang, Hsu, Chung-Y., and Kao, Chia-Hung
- Subjects
Adult ,Male ,Databases, Factual ,Incidence ,Age Factors ,Observational Study ,Comorbidity ,Kaplan-Meier Estimate ,Middle Aged ,Risk Assessment ,Peripheral Arterial Disease ,Sex Factors ,Risk Factors ,Diabetes Mellitus ,Humans ,Female ,Spinal Cord Injuries ,Research Article ,Aged ,Proportional Hazards Models ,Retrospective Studies - Abstract
The aim of this study was to elucidate the relationship between spinal cord injury (SCI) and the risk of peripheral arterial disease (PAD) in a cohort study with a large representative sample. The National Health Insurance Database was used to select patients who were diagnosed from 2000 to 2010. Patients with a history of PAD were excluded. The SCI group comprised 42,673 patients diagnosed with SCI, and we enrolled 170,389 matched controls (non-SCI group). We used a Cox proportional hazards regression model to analyze the adjusted risk of PAD between the case and control patients. Patients with SCI exhibited a significantly higher risk (hazard ratio [HR] = 1.37; 95% confidence interval [CI] = 1.22–1.53) of PAD than patients without SCI. Patients with diabetes were at the highest risk of developing PAD (adjusted HR = 3.11, 95% CI = 2.80–3.44). Among patients without comorbidity, SCI patients exhibited a significantly higher risk of PAD than non-SCI patients. Furthermore, lumbar, sacral, or coccygeal spine, and multiple spine SCI were significantly associated with an increased risk of PAD (HR = 1.56, 95% CI = 1.33–1.84, HR = 2.11, 95% CI = 1.59–2.79, respectively). SCI is associated with an increased risk of PAD. Future studies should focus on modifying risk factors to reduce PAD risk among patients with SCI.
- Published
- 2015