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1. T-Cell Acute Lymphoblastic Leukemia with Severe Leukopenia: Evidence for Suppression of Myeloid Progenitor Cells by Leukemic Blasts

Author

Dan Douer, Paul Froom, Nili Shaked, Isaac Ben-Bassat, and Bracha Ramot

Subjects
Adult, Male, T cell, Neutropenia, T-Lymphocytes, Regulatory, Colony-Forming Units Assay, Bone Marrow, hemic and lymphatic diseases, Acute lymphocytic leukemia, medicine, Humans, Leukemia-Lymphoma, Adult T-Cell, Leukopenia, business.industry, Lymphoblast, hemic and immune systems, Hematology, General Medicine, T lymphocyte, Hematopoietic Stem Cells, medicine.disease, Culture Media, Hematopoiesis, Haematopoiesis, Cell Transformation, Neoplastic, Phenotype, medicine.anatomical_structure, Immunology, Bone marrow, medicine.symptom, business
Abstract

A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.

Published
1988
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