1. FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C.
- Author
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So-Armah, Kaku A, Lim, Joseph K, Lo Re, Vincent, Tate, Janet P, Chang, Chung-Chou H, Butt, Adeel A, Gibert, Cynthia L, Rimland, David, Marconi, Vincent C, Goetz, Matthew Bidwell, Ramachandran, Vasan, Brittain, Evan, Long, Michelle, Nguyen, Kim-Lien, Rodriguez-Barradas, Maria C, Budoff, Matthew J, Tindle, Hilary A, Samet, Jeffrey H, Justice, Amy C, Freiberg, Matthew S, and VACS Project Team
- Subjects
VACS Project Team ,Humans ,Hepatitis C ,HIV Infections ,Liver Cirrhosis ,Anti-HIV Agents ,Stroke Volume ,Prognosis ,Viral Load ,Severity of Illness Index ,Incidence ,Risk Assessment ,Risk Factors ,Health Status ,Ventricular Function ,Left ,Time Factors ,Adult ,Middle Aged ,HIV Long-Term Survivors ,United States ,Female ,Male ,Heart Failure ,Veterans Health ,Cohort ,Ejection fraction ,HIV ,Heart failure ,Hepatitis ,Liver fibrosis ,Clinical Research ,Heart Disease ,Chronic Liver Disease and Cirrhosis ,Liver Disease ,Cardiovascular ,Digestive Diseases ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology - Abstract
BackgroundLiver fibrosis, is independently associated with incident heart failure (HF). Investigating the association between liver fibrosis and type of HF, specifically HF with reduced ejection fraction (EF; HFrEF) or HF with preserved ejection fraction (HFpEF), may provide mechanistic insight into this association. We sought to determine the association between liver fibrosis score (FIB-4) and type of HF, and to assess whether HIV or hepatitis C status modified this association.MethodsWe included patients alive on or after 4/1/2003 from the Veterans Aging Cohort Study. We followed patients without prevalent cardiovascular disease until their first HF event, death, last clinic visit, or 9/30/2015. We defined liver fibrosis as: likely advanced fibrosis (FIB-4 > 3.25), indeterminate (FIB-4 range 1.45-3.25), unlikely advanced fibrosis (FIB-4
- Published
- 2020