1. Nigella sativa and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Results from a randomized, double-blind, placebo-controlled, clinical trial
- Author
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Zahra Yari, Saeedeh Saadati, Behnam Hosseini-Ahangar, Mina Darand, Ahmad Khoncheh, Zahra Darabi, Seyed Moayyed Alavian, Mehdi Hedayati, and Azita Hekmatdoost
- Subjects
Adult ,Male ,Complementary and Manual Therapy ,medicine.medical_specialty ,Nigella sativa ,Disease ,Placebo ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Non-alcoholic Fatty Liver Disease ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Inflammation ,Advanced and Specialized Nursing ,biology ,Tumor Necrosis Factor-alpha ,business.industry ,C-reactive protein ,Fatty liver ,food and beverages ,Middle Aged ,medicine.disease ,Inflammatory biomarkers ,Clinical trial ,C-Reactive Protein ,Complementary and alternative medicine ,Dietary Supplements ,biology.protein ,Female ,Tumor necrosis factor alpha ,Plant Preparations ,business ,Biomarkers ,030217 neurology & neurosurgery ,Phytotherapy - Abstract
The aim of this study was to assess the effects of Nigella sativa consumption on inflammatory biomarkers in patients with Non-alcoholic fatty liver disease (NAFLD).This is a randomized, double-blind, placebo-controlled clinical trial. Fifty NAFLD patients were assigned to receive either two gram/day Nigella sativa seed as Nigella sativa group (NSG), or two gram/day starch as placebo group (PG) for 12 weeks.At the end of the study, the serum levels of tumor necrosis factor-α (TNF-α) decreased significantly compared with the beginning of the study in both groups, while the levels of high sensitive C reactive protein (hs-CRP) and nuclear factor kappa-B (NF-κB) only decreased significantly in the NSG (P 0 0.05). Only reduction in the serum levels of TNF-α was significantly more in NSG compared to the PG (P = 0.001). After adjusting the effects of confounding factors, the results remained unchanged. According to Fibroscan exam, hepatic steatosis and its percentage decreased significantly only in the NSG (P 0 0.005); however, the changes were not significantly different between two groups. After adjusting for confounding factors, only steatosis percentage reduction was significantly more in the NSG compared to PG (P = 0.005).Our results have shown that two gram/day consumption of Nigella sativa can reduce inflammatory biomarkers in patients with NAFLD. Further studies with different doses are highly recommended to find the optimal dosage.
- Published
- 2019