1. Structure-activity relationships of larvicidal monoterpenes and derivatives against Aedes aegypti Linn.
- Author
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Santos SR, Melo MA, Cardoso AV, Santos RL, de Sousa DP, and Cavalcanti SC
- Subjects
- Animals, Cyclohexenes toxicity, Insecticides chemistry, Larva drug effects, Limonene, Monoterpenes chemistry, Structure-Activity Relationship, Terpenes toxicity, Aedes drug effects, Insecticides toxicity, Monoterpenes toxicity
- Abstract
In the search for larvicidal compounds against Aedes aegypti L. (Diptera: Culicidae), a collection of monoterpenes were selected and evaluated. R- and S-limonene exhibited the highest larvicidal potency (LC(50)=27 and 30 ppm, respectively), followed by γ-terpinene (LC(50)=56 ppm) and RS-carvone (LC(50)=118 ppm). Structural characteristics which may contribute to the understanding of the larvicidal activity of monoterpenes were empirically identified. The presence of heteroatoms in the basic hydrocarbon structure decreases larvicidal potency. Conjugated and exo double bonds appear to increase larvicidal potency. Replacement of double bonds by more reactive epoxides decreases the larvicidal potency. The presence of hydroxyls in the cyclic structure resulted in decreased potency, probably due to increased polarity indicanting that lipophilicity seems to play an important role in increasing the larvicidal potency in this set of compounds., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2011
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