1. Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control.
- Author
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Nazni WA, Hoffmann AA, NoorAfizah A, Cheong YL, Mancini MV, Golding N, Kamarul GMR, Arif MAK, Thohir H, NurSyamimi H, ZatilAqmar MZ, NurRuqqayah M, NorSyazwani A, Faiz A, Irfan FMN, Rubaaini S, Nuradila N, Nizam NMN, Irwan SM, Endersby-Harshman NM, White VL, Ant TH, Herd CS, Hasnor AH, AbuBakar R, Hapsah DM, Khadijah K, Kamilan D, Lee SC, Paid YM, Fadzilah K, Topek O, Gill BS, Lee HL, and Sinkins SP
- Subjects
- Aedes genetics, Aedes metabolism, Animals, Dengue Virus metabolism, Dengue Virus pathogenicity, Female, Humans, Insect Vectors, Malaysia, Male, Mosquito Vectors, Wolbachia genetics, Aedes microbiology, Dengue prevention & control, Pest Control, Biological methods, Wolbachia metabolism
- Abstract
Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates., (Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2019
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