1. A 4-week exercise and protein program improves muscle mass and physical functioning in older adults - A pilot study
- Author
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Margot de Regt, Marlieke Visser, Maria T. E. Hopman, Marco Mensink, Pol Grootswagers, Jacintha Domić, Jaap Dronkers, and Ben J.M. Witteman
- Subjects
0301 basic medicine ,Male ,Aging ,medicine.medical_specialty ,Nutrition and Disease ,Prehabilitation ,Physical exercise ,Pilot Projects ,Isometric exercise ,Muscle mass ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Physical functioning ,Isometric Contraction ,Voeding en Ziekte ,Genetics ,Medicine ,Aerobic exercise ,Humans ,Muscle Strength ,Muscle, Skeletal ,Molecular Biology ,Exercise ,Supervised training ,Aged ,VLAG ,Human Nutrition & Health ,Hand Strength ,business.industry ,Protein ,Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6] ,Humane Voeding & Gezondheid ,VO2 max ,Resistance Training ,Cell Biology ,Nutritional Biology ,Ageing ,030104 developmental biology ,Physical therapy ,Physical function ,Female ,business ,030217 neurology & neurosurgery - Abstract
Contains fulltext : 229788.pdf (Publisher’s version ) (Open Access) BACKGROUND: Prehabilitation might attenuate common surgery-induced losses in muscle mass and physical performance. Beneficial effects of physical exercise with protein supplementation have been reported in older adults, but typically after an intervention of at least 12 weeks. The time-window for pre-surgery training is often limited to around 30 days, and it is not known if it is possible to achieve comparable results in such a short time window. OBJECTIVES: The aim of this study was to pilot-test the effectiveness of a controlled four-week combined exercise and protein supplementation program on skeletal muscle-related outcomes in a Dutch older adult population. DESIGN: This study was a one-armed pilot trial. PARTICIPANTS: Seventeen older men and women, aged 55-75y, not scheduled for surgery. INTERVENTION: A 4-week intervention program consisting of a twice-weekly supervised resistance and high-intensity aerobic exercise training of 75 min, combined with daily protein supplementation (2 doses of 15.5 g/day at breakfast and lunch). MEASUREMENT: After two and four weeks, isometric quadriceps maximal voluntary contraction (MVC) was assessed via Biodex and quadriceps cross-sectional area (CSA) via magnetic resonance imaging. Other outcome measures were handgrip strength, chair rise time and maximal aerobic capacity (VO(2)-max), as assessed from a submaximal exercise test. RESULTS: Compliance to the supervised training sessions (99.3%) and the protein supplementation (97%) was very high. The 4-week exercise and protein program led to an increase in quadriceps CSA of 2.3 ± 0.7 cm(2) (P = 0.008) in the dominant leg and 3.2 ± 0.7 cm(2) (P
- Published
- 2020