1. Summary Report on the ISOBM TD-6 Workshop: Analysis of 20 Monoclonal Antibodies against Sialyl Lewisa and Related Antigens.
- Author
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Rye, P.D., Bovin, N.V., Vlasova, E.V., Molodyk, A.A., Baryshnikov, A., Kreutz, F.T., Garinther, W.I., Schultes, B.C., Noujaim, A.A., Madiyalakan, R., Magnani, J., Nilsson, O., Nilsson, K., Nustad, K., Norum, L., Bell, H., Cao, Y., Suresh, M.R., Very, D.L., and Freeman, J.V.
- Abstract
The ISOBM TD-6 Workshop is the first international workshop on monoclonal antibodies against the Sialyl Lewis
a (SLea ) antigen. Eight research groups participated in a blind study to characterize the epitope binding, relative affinity and performance in immunoradiometric assays, of a panel of 20 monoclonal antibodies. The antibodies were tested against a diverse panel of neoglycoconjugates, purified antigens and human serum pools from gastrointestinal malignancies. Epitope specificities were determined for the majority of antibodies in the panel. Cross-reactivity with related saccharide structures was noted in several antibodies. Overall, the results of the TD-6 Workshop show further development of SLea immunoassays may yield yet more specific assays for the detection and management of gastrointestinal and other malignancies. [ABSTRACT FROM AUTHOR]- Published
- 1998
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