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1. Rapamycin Rescues the Poor Developmental Capacity of Aged Porcine Oocytes

Author

Seung Eun Lee, Eun Young Kim, Hyun Yong Choi, Jeremiah Jiman Moon, Min Jee Park, Jun Beom Lee, Chang Jin Jeong, and Se Pill Park

Subjects
Porcine Oocyte, Age, Rapamycin, Reactive Oxygen Species (ROS), Mammalian Target of Rapamycin (mTOR), Animal culture, SF1-1100, Animal biochemistry, QP501-801
Abstract

Unfertilized oocytes age inevitably after ovulation, which limits their fertilizable life span and embryonic development. Rapamycin affects mammalian target of rapamycin (mTOR) expression and cytoskeleton reorganization during oocyte meiotic maturation. The goal of this study was to examine the effects of rapamycin treatment on aged porcine oocytes and their in vitro development. Rapamycin treatment of aged oocytes for 24 h (68 h in vitro maturation [IVM]; 44 h+10 μM rapamycin/24 h, 47.52±5.68) or control oocytes (44 h IVM; 42.14±4.40) significantly increased the development rate and total cell number compared with untreated aged oocytes (68 h IVM, 22.04±5.68) (p

Published
2014
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2. Rapamycin Rescues the Poor Developmental Capacity of Aged PorcineOocytes

Author

Hyun Yong Choi, Chang Jin Jeong, Eun-Young Kim, Seung-Eun Lee, Min Jee Park, Se Pill Park, Jun Beom Lee, and Jeremiah Jiman Moon

Subjects
MAPK/ERK pathway, lcsh:Animal biochemistry, Biology, Bioinformatics, Article, Andrology, Age, medicine, Rapamycin, lcsh:QP501-801, PI3K/AKT/mTOR pathway, Porcine Oocyte, Reactive Oxygen Species (ROS), MammalianTarget of Rapamycin (mTOR), lcsh:SF1-1100, Embryogenesis, Oocyte, In vitro maturation, medicine.anatomical_structure, Mammalian Target of Rapamycin (mTOR), DNA fragmentation, Spindle organization, Animal Science and Zoology, lcsh:Animal culture, MAP1LC3B, Food Science
Abstract

Unfertilized oocytes age inevitably after ovulation, which limits their fertilizable life span and embryonic development. Rapamycin affects mammalian target of rapamycin (mTOR) expression and cytoskeleton reorganization during oocyte meiotic maturation. The goal of this study was to examine the effects of rapamycin treatment on aged porcine oocytes and their in vitro development. Rapamycin treatment of aged oocytes for 24 h (68 h in vitro maturation [IVM]; 44 h+10 mu M rapamycin/24 h, 47.52 +/- 5.68) or control oocytes (44 h IVM; 42.14 +/- 4.40) significantly increased the development rate and total cell number compared with untreated aged oocytes (68 h IVM, 22.04 +/- 5.68) (p

Published
2014

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