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1. Genetic and chemotherapeutic influences on germline hypermutation

Author

Joanna, Kaplanis, Benjamin, Ide, Rashesh, Sanghvi, Matthew, Neville, Petr, Danecek, Tim, Coorens, Elena, Prigmore, Patrick, Short, Giuseppe, Gallone, Jeremy, McRae, Jenny, Carmichael, Angela, Barnicoat, Helen, Firth, Patrick, O'Brien, Raheleh, Rahbari, and Chris, Odhams

Subjects
Male, Parents, Germ Cells, Mutagenesis, Mutation, Age Factors, Genetic Diseases, Inborn, Humans, Polymorphism, Single Nucleotide, Germ-Line Mutation
Abstract

Mutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual's genome

Published
2021

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