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Objective. To estimate the prevalence of non-fatal road traffic injuries (RTIs), their characteristics, trend and consequences in the Mexican population. Materials and methods. A descriptive study using data from the National Health and Nutrition Survey (Ensanut Continua 2021-2023), designed with probabilistic, multistage, and stratified sampling. The prevalence of RTIs by sex, age group, region, residence area, well-being index, and type of road user was estimated, as the proportion of use of protective measures and health consequences. Results. The prevalence of non-fatal RTIs was 1.31% (95%CI: 1.1,1.5), approximately 1.6 million individuals, of whom more than 90% required medical attention and 28.4% reported a permanent health consequence. They were more frequent in urban areas and the regions of Estado de México and Peninsula (79.1, 15.1, and 14.1%, respectively), in males (71.1%), and in motorcycle users. Conclusions. The increase in the prevalence of nonfatal RTIs and the persistence of risky road safety behaviors underline the urgency of strengthening public policies and their implementation. [ABSTRACT FROM AUTHOR]